PMID- 10454360
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20240314
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 5
IP  - 4-5
DP  - 1998 Sep-Oct
TI  - Impaired eye-blink conditioning in waggler, a mutant mouse with cerebellar BDNF 
      deficiency.
PG  - 355-64
AB  - In addition to their trophic functions, neurotrophins are also implicated in 
      synaptic modulation and learning and memory. Although gene knockout techniques 
      have been used widely in studying the roles of neurotrophins at molecular and 
      cellular levels, behavioral studies using neurotrophin knockouts are limited by 
      the early-onset lethality and various sensory deficits associated with the gene 
      knockout mice. In the present study, we found that in a spontaneous mutant mouse, 
      waggler, the expression of brain-derived neurotrophic factor (BDNF) was 
      selectively absent in the cerebellar granule cells. The cytoarchitecture of the 
      waggler cerebellum appeared to be normal at the light microscope level. The 
      mutant mice exhibited no sensory deficits to auditory stimuli or heat-induced 
      pain. However, they were massively impaired in classic eye-blink conditioning. 
      These results suggest that BDNF may have a role in normal cerebellar neuronal 
      function, which, in turn, is essential for classic eye-blink conditioning.
FAU - Bao, S
AU  - Bao S
AD  - Neuroscience Program, University of Southern California, Los Angeles 90089, USA.
FAU - Chen, L
AU  - Chen L
FAU - Qiao, X
AU  - Qiao X
FAU - Knusel, B
AU  - Knusel B
FAU - Thompson, R F
AU  - Thompson RF
LA  - eng
GR  - 5P01-MH52194/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Auditory Cortex/physiology
MH  - Blinking/*physiology
MH  - Brain-Derived Neurotrophic Factor/*deficiency/genetics/*physiology
MH  - Cerebellum/cytology/*metabolism/*physiology
MH  - Conditioning, Classical/*physiology
MH  - Electromyography
MH  - Electroshock
MH  - Extinction, Psychological
MH  - Fear
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Neurologic Mutants
MH  - Neurons/*physiology
MH  - Pain/physiopathology
MH  - RNA, Messenger/analysis
MH  - Reaction Time
MH  - Transcription, Genetic
PMC - PMC311271
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
PMCR- 1999/09/01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
PHST- 1999/09/01 00:00 [pmc-release]
PST - ppublish
SO  - Learn Mem. 1998 Sep-Oct;5(4-5):355-64.