PMID- 10456089
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20191103
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 3
IP  - 2-3
DP  - 1996 Sep-Oct
TI  - Determinants of BDNF-induced hippocampal synaptic plasticity: role of the Trk B 
      receptor and the kinetics of neurotrophin delivery.
PG  - 188-96
AB  - The neurotrophins are a class of signaling molecules known for their growth and 
      survival-promoting activities during neuronal development. Recent studies suggest 
      that the neurotrophins, including brain-derived neurotrophic factor (BDNF), can 
      also dramatically influence synaptic transmission in the adult hippocampus. The 
      experiments described in this paper indicate that ability of BDNF to potentiate 
      synaptic transmission in the hippocampus relies on functional Trk B receptors. 
      Moreover, the rate at which BDNF is applied to hippocampal synapses is also a 
      potent determinant of whether synaptic potentiation will result. Hippocampal 
      slices perfused with BDNF at a very slow flow rate (e.g., < or = 25 ml/hr) did 
      not show synaptic potentiation. Increasing the rate of BDNF application resulted 
      in synaptic potentiation in which the magnitude and onset kinetics of the 
      potentiation were determined by the rate of BDNF delivery. Immunocytochemical 
      analysis of BDNF detected with confocal microscopy confirmed these 
      electrophysiological observations, indicating that the penetration of BDNF into 
      hippocampal slices is influenced dramatically by the perfusion rate.
FAU - Kang, H
AU  - Kang H
AD  - Division of Biology, California Institute of Technology, Pasadena 91125, USA.
FAU - Jia, L Z
AU  - Jia LZ
FAU - Suh, K Y
AU  - Suh KY
FAU - Tang, L
AU  - Tang L
FAU - Schuman, E M
AU  - Schuman EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacokinetics/*pharmacology
MH  - Hippocampus/*drug effects/metabolism/physiology
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Male
MH  - Microscopy, Confocal
MH  - Nerve Growth Factors/*metabolism
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*physiology
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/*physiology
MH  - Synapses/*drug effects/physiology
EDAT- 1996/09/01 00:00
MHDA- 1999/08/24 00:01
CRDT- 1996/09/01 00:00
PHST- 1996/09/01 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1996/09/01 00:00 [entrez]
AID - 10.1101/lm.3.2-3.188 [doi]
PST - ppublish
SO  - Learn Mem. 1996 Sep-Oct;3(2-3):188-96. doi: 10.1101/lm.3.2-3.188.