PMID- 10456117
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20191210
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 3
IP  - 6
DP  - 1997 Mar-Apr
TI  - Acquisition of a new-latency conditioned nictitating membrane response--major, 
      but not complete, dependence on the ipsilateral cerebellum.
PG  - 557-77
AB  - Classical conditioning of the nictitating membrane response (NMR) of rabbits is 
      simple associative learning of a motor response. In several two-stage 
      experiments, reversible inactivations of the deep cerebellar nuclei in stage 1 
      appeared to prevent acquisition of NMR conditioning in naive rabbits--no 
      conditioned responses (CRs) were evident after inactivations were lifted in stage 
      2. Results of a three-stage experiment were different. When subjects were first 
      trained with a light conditional stimulus (CS) in stage 1, reversible cerebellar 
      inactivations during conditioning to a different, tone CS during stage 2 did not 
      appear to prevent new learning because CRs to the tone CS were evident when the 
      inactivation was lifted. Results from the two-stage experiments support the 
      suggestion that the cerebellum is essential for the acquisition of NMR 
      conditioning, but results from the three-stage experiment do not. Here, we use a 
      three-stage design with different interstimulus intervals (ISIs) in stages 1 and 
      2. Because CRs develop with latencies-to-peak dependent on the ISI, learning 
      during stage 1 can be dissociated from that accruing in stage 2. Complete 
      inactivation of the ipsilateral cerebellar nuclei with muscimol substantially but 
      not completely prevented learning with the second ISI during stage 2 because 
      small CR peaks around the stage 2 ISI could be detected in some subjects after 
      the inactivation had been lifted in stage 3. We suggest that the weak levels of 
      conditioning possible during unilateral inactivation depend on the contralateral 
      cerebellum or on extracerebellar circuitry and that these may be capable of 
      supporting transfer of conditioning in a previous three-stage experiment. But, we 
      confirm that normal NMR conditioning is critically dependent on the ipsilateral 
      cerebellum.
FAU - Yeo, C H
AU  - Yeo CH
AD  - Department of Anatomy and Developmental Biology, University College London, UK.
FAU - Lobo, D H
AU  - Lobo DH
FAU - Baum, A
AU  - Baum A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (GABA Agonists)
RN  - 2763-96-4 (Muscimol)
SB  - IM
MH  - Animals
MH  - Cerebellum/*physiology
MH  - Conditioning, Psychological/drug effects/*physiology
MH  - GABA Agonists/pharmacology
MH  - Male
MH  - Muscimol/pharmacology
MH  - Nictitating Membrane/*physiology
MH  - Rabbits
MH  - Reaction Time/physiology
EDAT- 1997/03/01 00:00
MHDA- 1999/08/24 00:01
CRDT- 1997/03/01 00:00
PHST- 1997/03/01 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1997/03/01 00:00 [entrez]
AID - 10.1101/lm.3.6.557 [doi]
PST - ppublish
SO  - Learn Mem. 1997 Mar-Apr;3(6):557-77. doi: 10.1101/lm.3.6.557.