PMID- 10456426
OWN - NLM
STAT- MEDLINE
DCOM- 19991027
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 377
IP  - 2-3
DP  - 1999 Jul 21
TI  - Distinct features of seizures induced by cocaine and amphetamine analogs.
PG  - 167-73
AB  - Seizure-related emergencies caused by stimulants of abuse have been increasing. 
      To better understand the nature of these drug-induced convulsions, we 
      characterized the seizure patterns associated with high doses of cocaine, and the 
      amphetamine analogs, methamphetamine, methylenedioxymethamphetamine (MDMA) and 
      4-methylaminorex. The features of the stimulant-induced seizures were distinct 
      and included the following: (1) the duration of convulsive activity was shortest 
      for cocaine and longest for methamphetamine, (2) only MDMA produced a secondary 
      clonic phase after the initial ictal event, and (3) 4-methylaminorex manifested a 
      very steep dose-response curve. Differential preventive profiles of 
      anticonvulsant agents on the stimulant-induced seizures also were observed. For 
      example, cocaine-related seizures were most effectively prevented by, while 
      methamphetamine-induced seizures were completely refractory to, phenytoin 
      pretreatment. The only anticonvulsants which appeared to influence 
      methamphetamine-related convulsions were diazepam and valproate. A unique feature 
      of 4-methylaminorex was that related seizures were almost completely blocked by 
      the calcium channel blocker, flunarizine.
FAU - Hanson, G R
AU  - Hanson GR
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 
      84112, USA.
FAU - Jensen, M
AU  - Jensen M
FAU - Johnson, M
AU  - Johnson M
FAU - White, H S
AU  - White HS
LA  - eng
GR  - DA 00869/DA/NIDA NIH HHS/United States
GR  - DA 04222/DA/NIDA NIH HHS/United States
GR  - K05 DA00378/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 0 (Oxazoles)
RN  - 44RAL3456C (Methamphetamine)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - 7PK6VC94OU (4-methylaminorex)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - Q3JTX2Q7TU (Diazepam)
RN  - R7PLA2DM0J (Flunarizine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Agents/*toxicity
MH  - Central Nervous System Stimulants/toxicity
MH  - Diazepam/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Flunarizine/pharmacology
MH  - Hallucinogens/toxicity
MH  - Male
MH  - Methamphetamine/*toxicity
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Oxazoles/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/chemically induced/*prevention & control
MH  - Time Factors
MH  - Valproic Acid/pharmacology
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - S0014-2999(99)00419-7 [pii]
AID - 10.1016/s0014-2999(99)00419-7 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1999 Jul 21;377(2-3):167-73. doi: 10.1016/s0014-2999(99)00419-7.