PMID- 10458328
OWN - NLM
STAT- MEDLINE
DCOM- 19991006
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 54
IP  - 1
DP  - 1999 Jul
TI  - Histocompatibility antigens and alleles in Japanese haemophilia A patients with 
      or without factor VIII antibodies.
PG  - 91-7
AB  - We carried out human leukocyte antigen (HLA)-A, B, Cw, DR and DQ serological 
      typing and HLA-DQA1, DQB1, DRB1 and DPB1 genetic typing for 46 Japanese 
      haemophilia A patients, including 20 who had developed an antibody to factor 
      VIII. It appears that anti FVIII inhibitor formation is associated with the major 
      histocompatibility complex in Japanese haemophilia A patients. Absence of HLA-A24 
      is a principal risk factor for inhibitor formation in Japanese haemophilia A 
      patients. As supplemental risk factors, HLA-DR4.1, DQ4 and DQA1*0301=2 are 
      positively associated with patients exhibiting inhibitor compared with normal 
      subjects. This and previous studies show that the association between HLA 
      antigens and the formation of inhibitor depends on race. Data of HLA typing may 
      be useful for the recognition of groups at high risk for the possible formation 
      of inhibitor among Japanese haemophilia A patients.
FAU - Ohta, H
AU  - Ohta H
AD  - Japanese Red Cross Aichi Blood Centre, Seto.
FAU - Takahashi, I
AU  - Takahashi I
FAU - Kojima, T
AU  - Kojima T
FAU - Takamatsu, J
AU  - Takamatsu J
FAU - Shima, M
AU  - Shima M
FAU - Yoshioka, A
AU  - Yoshioka A
FAU - Saito, H
AU  - Saito H
FAU - Kamiya, T
AU  - Kamiya T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antibodies)
RN  - 0 (HLA Antigens)
RN  - 9001-27-8 (Factor VIII)
SB  - IM
MH  - *Alleles
MH  - Antibodies/blood/immunology
MH  - Factor VIII/*immunology
MH  - HLA Antigens/*genetics/immunology
MH  - Hemophilia A/blood/genetics/*immunology
MH  - Humans
MH  - Japan
EDAT- 1999/08/24 00:00
MHDA- 1999/08/24 00:01
CRDT- 1999/08/24 00:00
PHST- 1999/08/24 00:00 [pubmed]
PHST- 1999/08/24 00:01 [medline]
PHST- 1999/08/24 00:00 [entrez]
AID - 10.1034/j.1399-0039.1999.540111.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1999 Jul;54(1):91-7. doi: 10.1034/j.1399-0039.1999.540111.x.