PMID- 10459556
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 48
IP  - 8
DP  - 1999 Aug
TI  - Multivariate identification of metabolic features in inflammatory bowel disease.
PG  - 952-6
AB  - Weight loss and malnutrition are commonly reported in inflammatory bowel disease 
      (IBD), but differences between Crohn's disease (CD) and ulcerative colitis (UC) 
      patients have rarely been pointed out. In this regard, a sample of 102 
      consecutive patients with a diagnosis of either CD (n = 63, 33 males) or UC (n = 
      39, 25 males) based on previously reported clinical, morphologic, and 
      histopathologic criteria were studied. Twenty-six anthropometric and metabolic 
      variables were measured upon admission. Body composition was assessed by both 
      anthropometry and bioimpedance measurements, and energy expenditure and substrate 
      oxidation were assessed by indirect calorimetry. The data were subjected to 
      principal-component analysis and to factor rotation to derive a set of a few 
      basic independent descriptors of the metabolic features of each subject. Six 
      descriptors were found to be responsible for greater than 86% of the total sample 
      variability and to associate very well with mutually disjoint subsets of the 
      original variables. The six summarizing factors are listed in order of decreasing 
      percentage of explained variation (size 41.8%, fatness 17.9%, fuel 12.2%, shape 
      5.4%, energy 5.2%, and steroid 3.9%). CD and UC patients differed significantly 
      with respect to fatness (CD lower, P = .004) and carbohydrate (CHO) fuel 
      preference (CD lower, P = .030). Hence, CD patients showed a reduced fat mass 
      (FM) compared with UC patients, and from a metabolic point of view, too, CD and 
      UC are not superimposable. In fact, the lower CHO oxidation (CHOox) rate and 
      consequent preferential lipid utilization found in CD patients may be taken into 
      account as a contributing cause of lipid tissue wasting and in planning 
      therapeutic enteral regimens.
FAU - Capristo, E
AU  - Capristo E
AD  - Istituto di Medicina Interna and Consiglio Nazionale delle Richerche-Centro di 
      Studio per la Fisiopatologia dello Shock, Universita Cattolica del Sacro Cuore, 
      Rome, Italy.
FAU - De Gaetano, A
AU  - De Gaetano A
FAU - Mingrone, G
AU  - Mingrone G
FAU - Addolorato, G
AU  - Addolorato G
FAU - Greco, A V
AU  - Greco AV
FAU - Castagneto, M
AU  - Castagneto M
FAU - Gasbarrini, G
AU  - Gasbarrini G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anthropometry
MH  - *Body Weight
MH  - Female
MH  - Humans
MH  - Inflammatory Bowel Diseases/*metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - S0026-0495(99)90188-9 [pii]
AID - 10.1016/s0026-0495(99)90188-9 [doi]
PST - ppublish
SO  - Metabolism. 1999 Aug;48(8):952-6. doi: 10.1016/s0026-0495(99)90188-9.