PMID- 10460478
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20190905
IS  - 0340-2061 (Print)
IS  - 0340-2061 (Linking)
VI  - 200
IP  - 4
DP  - 1999 Oct
TI  - Axonal growth of newly formed vomeronasal receptor neurons after nerve 
      transection.
PG  - 413-7
AB  - Chemosensory neurons in the vomeronasal epithelium (vomeronasal neurons) 
      regenerate following experimentally induced degeneration. Transection of the 
      vomeronasal nerves leads to retrograde degeneration of vomeronasal neurons 
      followed by replacement of the cell population. The projection of the axons of 
      regenerated vomeronasal neurons was examined by horseradish peroxidase(HRP) 
      histochemistry and electron microscopy. HRP-wheat germ agglutinin (WGA) was 
      placed on the surface of the vomeronasal organ of the rat. Dense distribution of 
      HRP-labeled fibers was observed in the vomeronasal nerve and glomerular layers in 
      the accessory olfactory bulb (AOB) of the intact rat. At one week after 
      transection, HRP-labeled fibers were not found in the AOB, and no labeled fibers 
      could be observed on the medial surface of the olfactory bulb where the 
      vomeronasal nerve traversed. Three weeks after transection, labeled fiber bundles 
      were observed on the medial surface of the olfactory bulb in all animals. No 
      labeled fibers were detected in the AOB. From 12 to 32 weeks after transection, 
      projection of HRP-labeled fibers was identified in the AOB in 8 out of 26 rats 
      (the incidence of projection was 30%). But the number of projection fibers on the 
      operated side was much smaller than on the control side. Electron microscopy 
      confirmed that the HRP-labeled terminals make synaptic contacts with neurons in 
      the AOB.
FAU - Ichikawa, M
AU  - Ichikawa M
AD  - Core Research for Evolution, Science and Culture (CREST) of the Japan Science and 
      Technology Corporation, Kawaguchi, Saitama 332-0012, Japan. mich@tmin.ac.jp
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Anat Embryol (Berl)
JT  - Anatomy and embryology
JID - 7505194
RN  - 0 (Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate)
SB  - IM
MH  - Animals
MH  - Axons/chemistry/*physiology/ultrastructure
MH  - Histocytochemistry
MH  - Male
MH  - Microscopy, Electron
MH  - *Nerve Regeneration
MH  - Olfactory Receptor Neurons/chemistry/growth & development/injuries/*physiology
MH  - Rats
MH  - Time Factors
MH  - Vomeronasal Organ/*innervation
MH  - Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate/analysis
EDAT- 1999/08/25 00:00
MHDA- 1999/08/25 00:01
CRDT- 1999/08/25 00:00
PHST- 1999/08/25 00:00 [pubmed]
PHST- 1999/08/25 00:01 [medline]
PHST- 1999/08/25 00:00 [entrez]
AID - 92000413.429 [pii]
AID - 10.1007/s004290050290 [doi]
PST - ppublish
SO  - Anat Embryol (Berl). 1999 Oct;200(4):413-7. doi: 10.1007/s004290050290.