PMID- 10461359
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20181113
IS  - 0044-0086 (Print)
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Linking)
VI  - 71
IP  - 3-4
DP  - 1998 May-Aug
TI  - Natural history, clinicopathologic classification and prognosis of gastric ECL 
      cell tumors.
PG  - 285-90
AB  - A series of 50 gastric endocrine tumors classified according to Rindi et al. [1] 
      comprised 12 small cell neuroendocrine carcinomas (NEC) and 38 ECL cell 
      carcinoids, of which 22 associated with type A chronic atrophic gastritis 
      (A-CAG), eight with hypertrophic gastropathy due to combined Multiple Endocrine 
      Neoplasia and Zollinger/Ellison syndrome (MEN/ZES), and eight sporadic. Variables 
      found to predict tumor malignancy were: size > 2 cm, > 2 mitoses and > 130 Ki67 
      positive cells/10 high power fields (HPF), grade 2 or 3 histology, angioinvasion, 
      p53 protein nuclear accumulation, and the presence of a single tumor. None of 
      these factors increased significantly the predicting ability of tumor 
      classification itself, although grade 2 + 3 shows 100 percent negative predictive 
      value and Ki67 and angioinvasion 100 percent positive predictive value. When the 
      mostly non-malignant A-CAG and MEN-ZES tumors were analysed against the mostly 
      malignant sporadic and NEC tumors, a positive predictive value of 90 percent and 
      a negative predictive value of 93 percent was obtained. Investigation of a larger 
      tumor series is under way with the aim to develop an optimal model for prognostic 
      evaluation of gastric endocrine tumors.
FAU - Solcia, E
AU  - Solcia E
AD  - Department of Human Pathology, University of Pavia, Italy.
FAU - Rindi, G
AU  - Rindi G
FAU - Paolotti, D
AU  - Paolotti D
FAU - Luinetti, O
AU  - Luinetti O
FAU - Klersy, C
AU  - Klersy C
FAU - Zangrandi, A
AU  - Zangrandi A
FAU - La Rosa, S
AU  - La Rosa S
FAU - Capella, C
AU  - Capella C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
RN  - 0 (Gastrins)
RN  - 333DO1RDJY (Serotonin)
RN  - 51110-01-1 (Somatostatin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma/pathology
MH  - Cell Differentiation
MH  - Cell Division
MH  - Enterochromaffin-like Cells/metabolism/*pathology
MH  - Female
MH  - Gastrins/metabolism
MH  - Gastritis, Atrophic/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitosis
MH  - Neuroendocrine Tumors/classification/*pathology/secondary
MH  - Predictive Value of Tests
MH  - Regression Analysis
MH  - Serotonin/metabolism
MH  - Somatostatin/metabolism
MH  - Stomach Neoplasms/classification/*pathology/secondary
PMC - PMC2578994
EDAT- 1999/08/26 00:00
MHDA- 1999/08/26 00:01
PMCR- 1998/05/01
CRDT- 1999/08/26 00:00
PHST- 1999/08/26 00:00 [pubmed]
PHST- 1999/08/26 00:01 [medline]
PHST- 1999/08/26 00:00 [entrez]
PHST- 1998/05/01 00:00 [pmc-release]
PST - ppublish
SO  - Yale J Biol Med. 1998 May-Aug;71(3-4):285-90.