PMID- 10462761
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190915
IS  - 0165-6147 (Print)
IS  - 0165-6147 (Linking)
VI  - 20
IP  - 9
DP  - 1999 Sep
TI  - Emerging roles for RGS proteins in cell signalling.
PG  - 376-82
AB  - Regulators of G-protein signalling (RGS proteins) are a family of highly diverse, 
      multifunctional signalling proteins that share a conserved 120 amino acid domain 
      (RGS domain). RGS domains bind directly to activated Galpha subunits and act as 
      GTPase-activating proteins (GAPs) to attenuate and/or modulate hormone and 
      neurotransmitter receptor-initiated signalling by both Galpha-GTP and Gbetagamma. 
      Apart from this structural domain, which is shared by all known RGS proteins, 
      these proteins differ widely in their overall size and amino acid identity and 
      possess a remarkable variety of structural domains and motifs. These biochemical 
      features impart signalling functions and/or enable RGS proteins to interact with 
      a growing list of unexpected protein-binding partners with diverse cellular 
      roles. New appreciation for the broader cellular functions of RGS proteins 
      challenges established models of G-protein signalling and serves to identify 
      these proteins as central participants in receptor signalling and cell 
      physiology.
FAU - Hepler, J R
AU  - Hepler JR
AD  - Department of Pharmacology, Emory University School of Medicine, 5009 Rollins 
      Research Center, 1510 Clifton Road, Atlanta, GA 30322-3090, USA. 
      jhepler@emory.edu
LA  - eng
GR  - R01NS37112/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Pharmacol Sci
JT  - Trends in pharmacological sciences
JID - 7906158
RN  - 0 (Hormones)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Proteins)
RN  - 0 (RGS Proteins)
RN  - 0 (RGS12 protein, human)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Rgs2 protein, mouse)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - GTP-Binding Proteins/chemistry/*physiology
MH  - Hormones/physiology
MH  - Humans
MH  - Neurotransmitter Agents/physiology
MH  - Proteins/*physiology
MH  - *RGS Proteins
MH  - Receptors, Cell Surface/drug effects
MH  - *Signal Transduction
RF  - 84
EDAT- 1999/08/27 00:00
MHDA- 1999/08/27 00:01
CRDT- 1999/08/27 00:00
PHST- 1999/08/27 00:00 [pubmed]
PHST- 1999/08/27 00:01 [medline]
PHST- 1999/08/27 00:00 [entrez]
AID - S0165-6147(99)01369-3 [pii]
AID - 10.1016/s0165-6147(99)01369-3 [doi]
PST - ppublish
SO  - Trends Pharmacol Sci. 1999 Sep;20(9):376-82. doi: 10.1016/s0165-6147(99)01369-3.