PMID- 10463275
OWN - NLM
STAT- MEDLINE
DCOM- 19990928
LR  - 20191103
IS  - 1093-5266 (Print)
IS  - 1093-5266 (Linking)
VI  - 1
IP  - 1
DP  - 1998 Jan-Feb
TI  - National Wilms Tumor Study: an update for pathologists.
PG  - 79-84
AB  - The National Wilms Tumor Study (NWTS)-5, begun in August 1995, incorporates some 
      important new definitions and concepts that have critical importance in 
      determining therapy and prognosis. The criteria for stage 1 were refined to 
      accommodate an important subset of stage 1 Wilms tumors that are being managed by 
      nephrectomy alone, without the use of adjuvant therapy. The distinction between 
      stages 1 and 2 in the renal sinus is no longer defined by the hilar plane but by 
      the presence or absence of venous or lymphatic invasion. Specific problems 
      encountered in the interpretation of the renal sinus are discussed here. The 
      topographical definition of focal anaplasia has proven to be of prognostic value 
      and is incorporated into the NWTS-5 study design.
FAU - Beckwith, J B
AU  - Beckwith JB
AD  - Department of Pathology and Human Anatomy, Loma Linda University, CA 92350, USA.
LA  - eng
GR  - CA 42326/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
SB  - IM
MH  - Anaplasia/pathology
MH  - Disease Progression
MH  - Humans
MH  - Kidney Neoplasms/*pathology
MH  - Neoplasm Staging
MH  - Wilms Tumor/*pathology/therapy
RF  - 14
EDAT- 1999/08/27 00:00
MHDA- 1999/08/27 00:01
CRDT- 1999/08/27 00:00
PHST- 1999/08/27 00:00 [pubmed]
PHST- 1999/08/27 00:01 [medline]
PHST- 1999/08/27 00:00 [entrez]
AID - 10.1007/s100249900010 [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 1998 Jan-Feb;1(1):79-84. doi: 10.1007/s100249900010.