PMID- 10464890
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190905
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 93
IP  - 4
DP  - 1999 Apr
TI  - Analysis of pleural fluid in idiopathic spontaneous pneumothorax; correlation of 
      eosinophil percentage with the duration of air in the pleural space.
PG  - 262-7
AB  - Pleural fluid analysis was performed in patients with idiopathic spontaneous 
      pneumothorax. The objective of the study was to define the cell differentiation, 
      and part of the cytokine profile, in relation to the duration of pneumothorax. In 
      the 23 consecutive patients (19 men, mean age 34.2 years, 17 smokers), pleural 
      fluid was obtained immediately after chest tube drainage (n = 6), or during 
      thoracoscopy (n = 17). Cytospins were carried out, and supernatant analysis of 
      the different cytokines was performed using sandwich ELISA. All concentrations 
      were corrected for dilution. The duration of the pneumothorax was correlated with 
      the rise in eosinophil percentage (r = 0.81, P < 0.00001) in pleural fluid. 
      RANTES, platelet-activating factor (PAF), and monocyte chemotactic protein-1 
      (MCP-1) were detectable but no relationship with eosinophils or duration of the 
      pneumothorax was found. Granulocyte-macrophage colony stimulating factor (GM-CSF) 
      and interluekin-8 (IL-8) were not detectable. Interleukin-5 (IL-5) concentration 
      correlated with the eosinophil concentration (r = 0.84, P = 0.037) and the 
      eosinophil percentage (r = 0.68, P = 0.005) in the pleural fluid. Idiopathic 
      spontaneous pneumothorax causes a time-related rise in the eosinophil percentage 
      in the pleural space, which correlates with the level of IL-5.
FAU - Smit, H J
AU  - Smit HJ
AD  - Department of Pulmonary Medicine, Free University Hospital, Amsterdam, The 
      Netherlands.
FAU - van den Heuvel, M M
AU  - van den Heuvel MM
FAU - Barbierato, S B
AU  - Barbierato SB
FAU - Beelen, R J
AU  - Beelen RJ
FAU - Postmus, P E
AU  - Postmus PE
LA  - eng
PT  - Journal Article
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Adult
MH  - *Cell Differentiation
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Male
MH  - Pleural Effusion/*pathology
MH  - Pneumothorax/*pathology
MH  - Prospective Studies
EDAT- 1999/08/28 00:00
MHDA- 1999/08/28 00:01
CRDT- 1999/08/28 00:00
PHST- 1999/08/28 00:00 [pubmed]
PHST- 1999/08/28 00:01 [medline]
PHST- 1999/08/28 00:00 [entrez]
AID - S0954-6111(99)90022-7 [pii]
AID - 10.1016/s0954-6111(99)90022-7 [doi]
PST - ppublish
SO  - Respir Med. 1999 Apr;93(4):262-7. doi: 10.1016/s0954-6111(99)90022-7.