PMID- 10465689
OWN - NLM
STAT- MEDLINE
DCOM- 19990825
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 38
IP  - 6
DP  - 1999 Jun
TI  - Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in 
      young rats: a possible correlation with the development of schizophrenia-like 
      deficits.
PG  - 857-69
AB  - It has been hypothesized that a deleterious key contribution to schizophrenia 
      (SZ) development is a failure of migration and setting of young neurons into 
      their appropriate cortical target sites, particularly in the entorhinal cortex 
      (EC). To test this hypothesis in an animal model, we injected, in pregnant rats, 
      on gestational day (GD) 9, or 10, or 11, or 12, the antimitotic compound 
      methylazoxymethanolacetate (MAM) known to cause EC neuronal loss. We investigated 
      whether or not EC disruption during prenatal development is able to affect 
      behavior, including memory and learning, and brain nerve growth factor (NGF). 
      Prenatally MAM treated young rats didn't display gross behavioral changes in 
      social interaction, open-field and novel object investigation tests. By contrast, 
      GD11 and GD12 MAM treated rats had a retardation in passive avoidance 
      acquisition, while, in GD12 animals, pain sensitivity was reduced. GD12 animals 
      also showed increased NGF in the EC and remaining cortex. MAM treated animals 
      showed no changes in paw NGF or substance P levels suggesting that the altered 
      nociceptive response is not related to local downregulation of these two 
      molecules. The possibility that these behavioral and biochemical alterations 
      might be associated with the onset of SZ is discussed.
FAU - Fiore, M
AU  - Fiore M
AD  - Institute of Neurobiology, CNR, Rome, Italy.
FAU - Talamini, L
AU  - Talamini L
FAU - Angelucci, F
AU  - Angelucci F
FAU - Koch, T
AU  - Koch T
FAU - Aloe, L
AU  - Aloe L
FAU - Korf, J
AU  - Korf J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Nerve Growth Factors)
RN  - 33507-63-0 (Substance P)
RN  - 592-62-1 (Methylazoxymethanol Acetate)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Behavior, Animal/*drug effects
MH  - Brain/*drug effects/metabolism
MH  - Disease Models, Animal
MH  - Exploratory Behavior/drug effects
MH  - Female
MH  - Methylazoxymethanol Acetate/*toxicity
MH  - Nerve Growth Factors/*metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - Schizophrenia/*chemically induced
MH  - Social Behavior
MH  - Substance P/analysis
EDAT- 1999/08/28 00:00
MHDA- 1999/08/28 00:01
CRDT- 1999/08/28 00:00
PHST- 1999/08/28 00:00 [pubmed]
PHST- 1999/08/28 00:01 [medline]
PHST- 1999/08/28 00:00 [entrez]
AID - S0028390899000076 [pii]
AID - 10.1016/s0028-3908(99)00007-6 [doi]
PST - ppublish
SO  - Neuropharmacology. 1999 Jun;38(6):857-69. doi: 10.1016/s0028-3908(99)00007-6.