PMID- 10466966
OWN - NLM
STAT- MEDLINE
DCOM- 19990915
LR  - 20190516
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 60
IP  - 3
DP  - 1999 Mar
TI  - Reliability of parental history of antibiotic use for Filipino children admitted 
      with acute lower respiratory tract infection.
PG  - 397-9
AB  - Parental history on antibiotic use and the urine antibacterial assay (UABA) 
      result were compared in a study on Filipino children with acute lower respiratory 
      tract infection (ALRI). Among 108 patients in whom urine for the UABA could be 
      collected prior to starting antibiotic treatment in the hospital, 59 (55%) 
      guardians reported preceding antibiotic use, 54% of whom were positive in the 
      UABA. In another 37 (34%), the UABA result was positive, indicating nonreported 
      use of antibiotics. Among 190 patients in whom urine could be collected only 
      after intravenous administration of antibiotic, the UABA demonstrated large 
      inhibition zones after the first dose in most patients but a negative result was 
      seen in 14 cases. The inhibition zone radius was significantly smaller for 
      chloramphenicol than for beta-lactam antibiotics (8.3 mm versus 16.1 mm after one 
      dose; 95% confidence intervals = 7.0-9.7 and 14.9-17.2, respectively). Parental 
      history on antibiotic use gives an underestimate of preceding antibiotic use in 
      children with ALRI in the Philippines. The result partly explains the low yield 
      of blood culture in many studies on ALRI, and stresses the need to develop new 
      diagnostic methods not based on culture for those organisms highly sensitive to 
      antibiotics such as Streptococcus pneumoniae and Haemophilus influenzae.
FAU - Sombrero, L
AU  - Sombrero L
AD  - Research Institute for Tropical Medicine, Manila, The Philippines.
FAU - Sunico, M E
AU  - Sunico ME
FAU - Quiambao, B
AU  - Quiambao B
FAU - Lucero, M
AU  - Lucero M
FAU - Gatchalian, S
AU  - Gatchalian S
FAU - Leinonen, M
AU  - Leinonen M
FAU - Ruutu, P
AU  - Ruutu P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Anti-Bacterial Agents/*therapeutic use/urine
MH  - Child, Preschool
MH  - Haemophilus Infections/*diagnosis/drug therapy
MH  - Haemophilus influenzae/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Medical History Taking
MH  - Philippines
MH  - Pneumococcal Infections/*diagnosis/drug therapy
MH  - Respiratory Tract Infections/*diagnosis/drug therapy
MH  - Self Medication/adverse effects
EDAT- 1999/08/31 00:00
MHDA- 1999/08/31 00:01
CRDT- 1999/08/31 00:00
PHST- 1999/08/31 00:00 [pubmed]
PHST- 1999/08/31 00:01 [medline]
PHST- 1999/08/31 00:00 [entrez]
AID - 10.4269/ajtmh.1999.60.397 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 1999 Mar;60(3):397-9. doi: 10.4269/ajtmh.1999.60.397.