PMID- 10467575
OWN - NLM
STAT- MEDLINE
DCOM- 19990924
LR  - 20191103
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 2
IP  - 3-4
DP  - 1995 May-Aug
TI  - Temporal specificity of long-term depression in parallel fiber--Purkinje synapses 
      in rat cerebellar slice.
PG  - 185-98
AB  - The phenomenon of cerebellar long-term depression (LTD), a decrease of synaptic 
      strength between the parallel fibers (PFs) and Purkinje cells after conjunctive 
      activation of PFs and the climbing fibers (CFs), is implicated as a cellular 
      mechanism for motor learning. We have characterized a field-potential recording 
      technique in cerebellar slice and have used the technique to examine the temporal 
      conditions for cerebellar LTD induction in an attempt to examine the relevance of 
      LTD to associative conditioning. Interstimulus intervals (ISIs) between onsets of 
      PF and CF activation and the number of paired stimuli (pairings) were examined. 
      LTD has distinct temporal specificity that seems to be constrained by inhibitory 
      interneurons and can be masked by excessive stimulation. When 100 paired stimuli 
      were given to PFs and CFs, LTD was induced with an ISI of 250 msec (PF activation 
      preceding CF activation). In contrast, a smaller forward (125 msec), simultaneous 
      (0 msec), or backward (-250 msec) ISIs were not effective for inducing LTD. 
      However, the blockade of GABAA receptor-mediated inhibition made it possible to 
      induce LTD with 100 pairs of simultaneous stimulations. Furthermore, by 
      increasing the number of pairings to 600, significant LTD was observed with all 
      four interstimulus intervals. These results suggest that temporal conditions for 
      LTD induction share some similarity to associative learning of discrete motor 
      responses.
FAU - Chen, C
AU  - Chen C
AD  - Neuroscience Program, University of Southern California, Los Angeles 90089-2520, 
      USA.
FAU - Thompson, R F
AU  - Thompson RF
LA  - eng
GR  - AF05142/AF/ACF HHS/United States
GR  - AG00093/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
SB  - IM
MH  - Animals
MH  - Cerebellum/*physiology
MH  - In Vitro Techniques
MH  - Neuronal Plasticity/*physiology
MH  - Purkinje Fibers/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Synapses/*physiology
EDAT- 1995/05/01 00:00
MHDA- 1999/09/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1999/09/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1101/lm.2.3-4.185 [doi]
PST - ppublish
SO  - Learn Mem. 1995 May-Aug;2(3-4):185-98. doi: 10.1101/lm.2.3-4.185.