PMID- 10468863
OWN - NLM
STAT- MEDLINE
DCOM- 19991026
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 106
IP  - 3
DP  - 1999 Sep
TI  - P53 deletion is not a frequent event in multiple myeloma.
PG  - 717-9
AB  - Recently a high incidence of interstitial deletion of the P53 locus has been 
      reported in multiple myeloma (MM) patients. Considering the importance of such an 
      event, we analysed 79 patients with advanced-stage disease using fluorescence in 
      situ hybridization (FISH). Strikingly, we found only 7/79 patients with a P53 
      deletion. In order to rule out any differences in probe selection, we reanalysed 
      all the patients with the same probe as that used in a previous study, and 
      confirmed the low incidence of P53 deletion (7/79, 9%). The only explanation is a 
      difference in hybridization efficiency. Since hybridization is far less efficient 
      on malignant plasma cells than on other bone marrow cells we suggest that this 
      poor hybridization efficiency may lead to a false P53 deletion.
FAU - Avet-Loiseau, H
AU  - Avet-Loiseau H
AD  - Laboratory of Haematology, University Hospital, Lille, France.
FAU - Li, J Y
AU  - Li JY
FAU - Godon, C
AU  - Godon C
FAU - Morineau, N
AU  - Morineau N
FAU - Daviet, A
AU  - Daviet A
FAU - Harousseau, J L
AU  - Harousseau JL
FAU - Facon, T
AU  - Facon T
FAU - Bataille, R
AU  - Bataille R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
CIN - Br J Haematol. 2000 Mar;108(4):886. PMID: 10792302
MH  - *Gene Deletion
MH  - Genes, p53/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Multiple Myeloma/*genetics
EDAT- 1999/09/01 00:00
MHDA- 1999/09/01 00:01
CRDT- 1999/09/01 00:00
PHST- 1999/09/01 00:00 [pubmed]
PHST- 1999/09/01 00:01 [medline]
PHST- 1999/09/01 00:00 [entrez]
AID - bjh1615 [pii]
AID - 10.1046/j.1365-2141.1999.01615.x [doi]
PST - ppublish
SO  - Br J Haematol. 1999 Sep;106(3):717-9. doi: 10.1046/j.1365-2141.1999.01615.x.