PMID- 10469455
OWN - NLM
STAT- MEDLINE
DCOM- 20000107
LR  - 20190816
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 26
IP  - 2
DP  - 1999 Oct
TI  - Amplification of the 11q23 region in acute myeloid leukemia.
PG  - 166-70
AB  - Cytogenetic abnormalities involving the 11q23 region are found in both acute 
      lymphoblastic leukemia (ALL) and myeloid leukemia (AML). Molecular consequences 
      of 11q23 translocations are the formation of chimeric genes, all of them 
      involving the MLL (mixed-lineage leukemia) gene. To evaluate the usefulness of 
      fluorescence in situ hybridization (FISH) in detecting MLL rearrangements in AML, 
      we analyzed 181 patients with an MLL-specific probe. Among them, we detected 
      three patients with multiple FISH signals, reflecting genomic amplification of 
      this chromosomal region. Extra copies of MLL have been reported previously in 
      four patients, but did not correspond to a true gene amplification. For the first 
      time, we describe genomic amplification of the 11q23 region (up to more than 50 
      copies) in AML patients. This genomic amplification could affect MLL, but other 
      genes in the vicinity could also be the primary target. Genes Chromosomes Cancer 
      26:166-170, 1999.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Avet-Loiseau, H
AU  - Avet-Loiseau H
AD  - Laboratory of Hematology, University Hospital, Nantes, France. 
      havetloiseau@chu-nantes.fr
FAU - Godon, C
AU  - Godon C
FAU - Li, J Y
AU  - Li JY
FAU - Daviet, A
AU  - Daviet A
FAU - Mellerin, M P
AU  - Mellerin MP
FAU - Talmant, P
AU  - Talmant P
FAU - Harousseau, J L
AU  - Harousseau JL
FAU - Bataille, R
AU  - Bataille R
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (DNA, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Aged
MH  - Bone Marrow/chemistry
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA, Neoplasm/isolation & purification
MH  - DNA-Binding Proteins/genetics
MH  - Female
MH  - Gene Amplification/*genetics
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
MH  - Translocation, Genetic
MH  - Zinc Fingers/genetics
EDAT- 1999/09/01 00:00
MHDA- 1999/09/01 00:01
CRDT- 1999/09/01 00:00
PHST- 1999/09/01 00:00 [pubmed]
PHST- 1999/09/01 00:01 [medline]
PHST- 1999/09/01 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199910)26:2<166::AID-GCC9>3.0.CO;2-P [pii]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Oct;26(2):166-70.