PMID- 10469525
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20071114
IS  - 0889-1591 (Print)
IS  - 0889-1591 (Linking)
VI  - 13
IP  - 3
DP  - 1999 Sep
TI  - The differential impact of training stress and final examination stress on 
      herpesvirus latency at the United States Military Academy at West Point.
PG  - 240-51
AB  - In this study, we searched for evidence for reactivation of three latent 
      herpesviruses, Epstein-Barr virus (EBV), herpes simplex virus type-1 (HSV-1), and 
      human herpesvirus 6 (HHV-6), in West Point cadets experiencing two different 
      stressors. Blood samples were obtained from cadets before and after a 6-week 
      training period known as "Cadet Basic Training" (CBT), at a baseline prior to 
      final examinations, and then once again during the week of final examinations. 
      Antibody titers to latent HSV-1, EBV, and HHV-6 were determined as a measure of 
      the steady-state expression of latent virus. EBV virus capsid antigen (VCA) IgG 
      antibody titers were unchanged in blood samples obtained prior to and immediately 
      after CBT. However, EBV antibody titers were significantly higher in the blood 
      sample obtained during examination week than in the baseline period before 
      examination; they were also higher than antibody titers before/after CBT. None of 
      the serum samples were positive for EBV VCA IgM antibodies, indicating that the 
      changes in antibody titers to EBV were not associated with recent EBV infections 
      in the class. No significant changes in antibody titers to HSV-1 or HSV-6 were 
      found over the identical time periods, including examination week. Academic 
      stress but not CBT modulated the steady-state expression of latent EBV, resulting 
      in the reactivation of latent virus. The same stressors, however, did not affect 
      the steady-state expression of latent HSV-1 or HSV-6, at least as measured by 
      changes in antibody titers. The data provide additional evidence of the impact of 
      different psychological stressors on the steady-state expression of latent 
      herpesviruses.
CI  - Copyright 1999 Academic Press.
FAU - Glaser, R
AU  - Glaser R
AD  - Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State 
      University Medical Center, Columbus, Ohio 43210, USA.
FAU - Friedman, S B
AU  - Friedman SB
FAU - Smyth, J
AU  - Smyth J
FAU - Ader, R
AU  - Ader R
FAU - Bijur, P
AU  - Bijur P
FAU - Brunell, P
AU  - Brunell P
FAU - Cohen, N
AU  - Cohen N
FAU - Krilov, L R
AU  - Krilov LR
FAU - Lifrak, S T
AU  - Lifrak ST
FAU - Stone, A
AU  - Stone A
FAU - Toffler, P
AU  - Toffler P
LA  - eng
GR  - CA16058/CA/NCI NIH HHS/United States
GR  - MH44660/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Herpes Simplex/*immunology/psychology
MH  - Herpesviridae Infections/immunology/psychology
MH  - Herpesvirus 1, Human/*immunology
MH  - Herpesvirus 4, Human/immunology
MH  - Herpesvirus 6, Human/immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Military Personnel/*psychology
MH  - Neuroimmunomodulation
MH  - Psychological Tests
MH  - Stress, Psychological/immunology/psychology/*virology
MH  - Students/psychology
MH  - Tumor Virus Infections/immunology/psychology
MH  - *Virus Latency
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - S0889-1591(99)90566-4 [pii]
AID - 10.1006/brbi.1999.0566 [doi]
PST - ppublish
SO  - Brain Behav Immun. 1999 Sep;13(3):240-51. doi: 10.1006/brbi.1999.0566.