PMID- 10470275
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20191103
IS  - 0939-1983 (Print)
IS  - 0939-1983 (Linking)
VI  - 15
DP  - 1999
TI  - Pathogenic aspects of measles virus infections.
PG  - 139-58
AB  - Measles virus (MV) infections normally cause an acute self limiting disease which 
      is resumed by a virus-specific immune response and leads to the establishment of 
      a lifelong immunity. Complications associated with acute measles can, on rare 
      occasions, involve the central nervous system (CNS). These are postinfectious 
      measles encephalitis which develops soon after infection, and, months to years 
      after the acute disease, measles inclusion body encephalitis (MIBE) and subacute 
      sclerosing panencephalitis (SSPE) which are based on a persistent MV infection of 
      brain cells. Before the advent of HIV, SSPE was the best studied slow viral 
      infection of the CNS, and particular restrictions of MV gene expression as well 
      as MV interactions with neural cells have revealed important insights into the 
      pathogenesis of persistent viral CNS infections. MV CNS complication do, however, 
      not large contribute to the high rate of mortality seen in association with acute 
      measles worldwide. The latter is due to a virus-induced suppression of immune 
      functions which favors the establishment of opportunistic infections. Mechanisms 
      underlying MV-mediated immunosuppression are not well understood. Recent studies 
      have indicated that MV-induced disruption of immune functions may be 
      multifactorial including the interference with cytokine synthesis, the induction 
      of soluble inhibitory factors or apoptosis and negative signalling to T cells by 
      the viral glycoproteins expressed on the surface of infected cells, particularly 
      dendritic cells.
FAU - Schneider-Schaulies, S
AU  - Schneider-Schaulies S
AD  - Institute of Virology and Immunobiology, University of Wurzburg, Germany.
FAU - ter Meulen, V
AU  - ter Meulen V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Austria
TA  - Arch Virol Suppl
JT  - Archives of virology. Supplementum
JID - 9214275
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Animals
MH  - Encephalitis, Viral/*virology
MH  - Genes, Viral
MH  - Humans
MH  - Immune Tolerance
MH  - Measles/complications/immunology/transmission/*virology
MH  - Measles virus/genetics/immunology/*pathogenicity/physiology
MH  - Subacute Sclerosing Panencephalitis/*virology
MH  - Viral Proteins/physiology
RF  - 79
EDAT- 1999/09/02 00:00
MHDA- 1999/09/02 00:01
CRDT- 1999/09/02 00:00
PHST- 1999/09/02 00:00 [pubmed]
PHST- 1999/09/02 00:01 [medline]
PHST- 1999/09/02 00:00 [entrez]
AID - 10.1007/978-3-7091-6425-9_10 [doi]
PST - ppublish
SO  - Arch Virol Suppl. 1999;15:139-58. doi: 10.1007/978-3-7091-6425-9_10.