PMID- 10471611
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20081121
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 160
IP  - 3
DP  - 1999 Sep
TI  - Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse 
      airways.
PG  - 873-8
AB  - Interleukin-18 (IL-18) has recently been identified as an IFN-gamma-inducing 
      factor. Previous studies have shown that CD4(+) T cells, IL-5, and TNF-alpha 
      mediate, but IFN-gamma and IL-12 (via IFN-gamma production) inhibit 
      antigen-induced eosinophil recruitment into the airways of sensitized mice. Here, 
      we showed that the administration of recombinant murine IL-18 enhanced 
      antigen-induced eosinophil recruitment into the trachea and bronchoalveolar 
      lavage fluids (BALF) of sensitized mice in a dose-dependent manner. The 
      administration of IL-18 enhanced antigen-induced IFN-gamma and TNF-alpha 
      production, but not IL-5 production, in the BALF and lungs of sensitized mice. 
      Neutralizing antibody against TNF-alpha prevented antigen-induced eosinophil 
      recruitment into the BALF of sensitized mice. Although IL-18 enhanced 
      antigen-induced airway eosinophilia, IL-18 did not affect antigen-induced airway 
      hyperresponsiveness in sensitized mice. These results indicate that IL-18, unlike 
      IFN-gamma and IL-12, enhances antigen-induced eosinophil recruitment into the 
      airways in part by increasing antigen-induced TNF-alpha production of sensitized 
      animals. These findings suggest that IL-18 may contribute to the development and 
      exacerbation of airway inflammation in asthma.
FAU - Kumano, K
AU  - Kumano K
AD  - Departments of Medicine II and Physiology II, Chiba University School of 
      Medicine, Chiba, Japan.
FAU - Nakao, A
AU  - Nakao A
FAU - Nakajima, H
AU  - Nakajima H
FAU - Hayashi, F
AU  - Hayashi F
FAU - Kurimoto, M
AU  - Kurimoto M
FAU - Okamura, H
AU  - Okamura H
FAU - Saito, Y
AU  - Saito Y
FAU - Iwamoto, I
AU  - Iwamoto I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (Antigens)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-5)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antigens/*drug effects/immunology
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Eosinophils/*drug effects/immunology
MH  - Female
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18/immunology/*pharmacology
MH  - Interleukin-5/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Recombinant Proteins/immunology/pharmacology
MH  - Trachea/*drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
AID - 10.1164/ajrccm.160.3.9805026 [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 1999 Sep;160(3):873-8. doi: 
      10.1164/ajrccm.160.3.9805026.