PMID- 10472338
OWN - NLM
STAT- MEDLINE
DCOM- 19990916
LR  - 20051117
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 19
IP  - 3B
DP  - 1999 May-Jun
TI  - Biological characterization of central and peripheral primary non small cell lung 
      cancers (NSCLC).
PG  - 2249-52
AB  - BACKGROUND: Non Small Cell Lung Carcinomas (NSCLC) comprise 90% of all lung 
      carcinomas. Studies have demonstrated a preferential central (bronchus-derived) 
      localization for squamous cells, whereas adenocarcinomas are frequently 
      peripheral (bronchiolo-alveolus derived). It has been suggested that exposure to 
      carcinogenic insults including cigarette smoke, may induce different types of 
      tumors in different locations. MATERIALS AND METHODS: Forty one NSCLC patients 
      staged according to WHO and TNM were considered for localization and biological 
      parameters (p53 expression, cell ploidy and S-phase). RESULTS: p53 overexpression 
      was found more frequently in central than in peripheral tumors (69% vs 39%) (p = 
      0.074). Central tumors were more aneuploid (69%) than peripheral ones (46%) (p = 
      0.03) No difference in smoking habit was observed in the two groups. CONCLUSIONS: 
      Our results suggest that there is no apparent biological difference between these 
      two groups of NSCLCs, and that the smoking does not play a role in either 
      histotype determination or biological behavior.
FAU - Malara, N M
AU  - Malara NM
AD  - Institute of General Pathology and Cancer Research Center Giovanni XXIII, 
      Catholic University-School of Medicine, Rome, Italy.
FAU - Sgambato, A
AU  - Sgambato A
FAU - Granone, P
AU  - Granone P
FAU - Flamini, G
AU  - Flamini G
FAU - Margaritora, S
AU  - Margaritora S
FAU - Boninsegna, A
AU  - Boninsegna A
FAU - Cesario, A
AU  - Cesario A
FAU - Galetta, D
AU  - Galetta D
FAU - Yang, Q
AU  - Yang Q
FAU - Cittadini, A
AU  - Cittadini A
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Adenocarcinoma/pathology/surgery
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*pathology/surgery
MH  - Carcinoma, Squamous Cell/genetics/pathology/surgery
MH  - DNA, Neoplasm/analysis
MH  - Diploidy
MH  - Female
MH  - Flow Cytometry
MH  - Genes, p53
MH  - Humans
MH  - Immunohistochemistry
MH  - Lung/anatomy & histology/*pathology
MH  - Lung Neoplasms/genetics/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Smoking
MH  - Tumor Suppressor Protein p53/analysis
EDAT- 1999/09/03 00:00
MHDA- 1999/09/03 00:01
CRDT- 1999/09/03 00:00
PHST- 1999/09/03 00:00 [pubmed]
PHST- 1999/09/03 00:01 [medline]
PHST- 1999/09/03 00:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 1999 May-Jun;19(3B):2249-52.