PMID- 10473967
OWN - NLM
STAT- MEDLINE
DCOM- 19991118
LR  - 20171101
IS  - 0012-2823 (Print)
IS  - 0012-2823 (Linking)
VI  - 60
IP  - 5
DP  - 1999 Sep-Oct
TI  - Expression of vesicular monoamine transporters in endocrine hyperplasia and 
      endocrine tumors of the oxyntic stomach.
PG  - 428-39
AB  - BACKGROUND: Gastric enterochromaffin-like (ECL) cells selectively express the 
      vesicular monoamine transporter (VMAT) VMAT2, and enterochromaffin (EC) cells the 
      VMAT1 isoform. AIMS: We investigated whether VMAT isoform selection indicates the 
      origin of endocrine hyperplasia and neoplasia from oxyntic ECL or EC cells and 
      may be of prognostic significance in different types of gastric carcinoids. 
      METHODS: Tissue from patients with chronic atrophic gastritis (CAG), 
      Zollinger-Ellison-syndrome (ZES), gastric carcinoids and neuroendocrine carcinoma 
      (NEC) was investigated by immunohistology and in situ hybridization. RESULTS: 
      Endocrine cells forming diffuse, linear, and micronodular hyperplasia in CAG and 
      ZES, as well as oxyntic microcarcinoids expressed both VMAT2 and chromogranin A 
      (CgA) but neither VMAT1 nor serotonin. In five of six sporadic carcinoids VMAT2 
      and CgA but not VMAT1 were detected. One carcinoid was copositive for VMAT1 and 
      serotonin but negative for VMAT2. Electron microscopy confirmed the 
      VMAT2-positive tumors as ECLoma and the VMAT1-immunoreactive carcinoid as EComa. 
      CONCLUSIONS: VMAT2 and VMAT1 are reliable markers for differentiation of gastric 
      endocrine hyperplasia and neoplasia from ECL and EC cells, respectively. The 
      significance of VMAT2 and VMAT1 as prognostic markers lies in the relatively poor 
      prognosis for EComa compared to ECLoma, characterized by VMAT2 positivity. The 
      absence of both VMAT2 and VMAT1 in NEC may indicate poor prognosis.
FAU - Eissele, R
AU  - Eissele R
AD  - Department of Gastroenterology and Endocrinology, Institute of Anatomy and Cell 
      Biology, Philipps University, Marburg, Germany.
FAU - Anlauf, M
AU  - Anlauf M
FAU - Schafer, M K
AU  - Schafer MK
FAU - Eiden, L E
AU  - Eiden LE
FAU - Arnold, R
AU  - Arnold R
FAU - Weihe, E
AU  - Weihe E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
RN  - 0 (Biogenic Monoamines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biogenic Monoamines/*metabolism
MH  - Carcinoid Tumor/*metabolism/pathology
MH  - Enterochromaffin Cells/metabolism/pathology
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*metabolism/pathology
MH  - Stomach Neoplasms/*metabolism/pathology
MH  - Zollinger-Ellison Syndrome/*metabolism/pathology
EDAT- 1999/09/04 00:00
MHDA- 1999/09/04 00:01
CRDT- 1999/09/04 00:00
PHST- 1999/09/04 00:00 [pubmed]
PHST- 1999/09/04 00:01 [medline]
PHST- 1999/09/04 00:00 [entrez]
AID - 7688 [pii]
AID - 10.1159/000007688 [doi]
PST - ppublish
SO  - Digestion. 1999 Sep-Oct;60(5):428-39. doi: 10.1159/000007688.