PMID- 10477104
OWN - NLM
STAT- MEDLINE
DCOM- 20000121
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 271
IP  - 2
DP  - 1999 Aug 20
TI  - Age-related decrease in brain-derived neurotrophic factor gene expression in the 
      brain of the zitter rat with genetic spongiform encephalopathy.
PG  - 69-72
AB  - The zitter rat exhibits a progressive degradation in neuronal cells and genetic 
      spongiform encephalopathy with age. In order to elucidate the involvement of the 
      expression of the neurotrophic factor in neuropathology of the rat, we quantified 
      mRNA levels of neurotrophic factors (nerve growth factor, brain-derived 
      neurotrophic factor (BDNF), and neurotrophin-3, ciliary neurotrophic factor and 
      glial-cell-line-derived neurotrophic factor) in the zitter rat brain. Expression 
      of the BDNF gene was lower in the zitter rat brain (cerebrum, cerebellum, and 
      brainstem regions). Interestingly, kinase activity of mitogen activated protein 
      kinase (MAPK) Erk2 involved in the expression of BDNF was also down regulated, 
      despite an unchanging expression of MAPK protein. These results show the possible 
      involvement of a MAPK pathway in BDNF mRNA reduction in the zitter rat brain.
FAU - Muto, Y
AU  - Muto Y
AD  - Department of Molecular Biology, Tottori University Faculty of Medicine, Yonago, 
      Japan.
FAU - Hayashi, T
AU  - Hayashi T
FAU - Higashi, Y
AU  - Higashi Y
FAU - Endo, T
AU  - Endo T
FAU - Yamamoto, T
AU  - Yamamoto T
FAU - Sato, K
AU  - Sato K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/*genetics
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Western
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics/*metabolism
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Prion Diseases/*genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 1999/09/07 00:00
MHDA- 1999/09/07 00:01
CRDT- 1999/09/07 00:00
PHST- 1999/09/07 00:00 [pubmed]
PHST- 1999/09/07 00:01 [medline]
PHST- 1999/09/07 00:00 [entrez]
AID - S0304-3940(99)00532-7 [pii]
AID - 10.1016/s0304-3940(99)00532-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Aug 20;271(2):69-72. doi: 10.1016/s0304-3940(99)00532-7.