PMID- 10477400
OWN - NLM
STAT- MEDLINE
DCOM- 19991018
LR  - 20131121
IS  - 1148-5493 (Print)
IS  - 1148-5493 (Linking)
VI  - 10
IP  - 3
DP  - 1999 Sep
TI  - Tumor necrosis factor-alpha and its soluble receptors in plasma and cerebrospinal 
      fluid of multiple sclerosis patients treated with methylprednisolone.
PG  - 431-6
AB  - Demyelination is the main pathological feature of multiple sclerosis (MS), a 
      chronic inflammatory disease of the central nervous system. Tumor necrosis 
      factor-alpha (TNF-alpha) can cause myelin damage and contribute to MS 
      pathogenesis. We measured plasma and cerebrospinal fluid (CSF) levels of 
      TNF-alpha and its soluble receptors, TNF-sRp55 and TNF-sRp75, in 18 patients with 
      active MS, and in neurological and healthy controls. The same determinations were 
      repeated on plasma and on CSF samples that were collected after the MS patients 
      had ended a six-day treatment with high-dose methylprednisolone (MP). Pre- and 
      post-treatment plasma and CSF TNF-alpha levels, when detectable, and those of 
      TNF-sRp75, did not vary, and were similar to those of controls. CSF TNF-sRp55 
      levels were higher in acute MS patients than in controls. Post-treatment CSF 
      TNF-sRp55 levels were higher than in the active phase of the disease. The MS 
      patients, who clinically improved, tended to have the highest CSF TNF-sRp55 
      levels. The increase was due to intrathecal TNF-sRp55 synthesis. Although it is 
      involved in MS pathogenesis, TNF-alpha is not detectable in plasma or in CSF 
      samples from MS patients in various phases of the disease. A better marker of 
      disease activity seems to be CSF TNF-sRp55 levels. The increased CSF levels of 
      TNF-sRp55 in response to MP circumstantially suggest that this receptor could 
      partially account for the beneficial effects of MP in acute MS.
FAU - Franciotta, D
AU  - Franciotta D
AD  - Neurological Institute "C. Mondino Foundation", via Palestro 3, I-27100 Pavia, 
      Italy. francid@mondino.it
FAU - Bergamaschi, R
AU  - Bergamaschi R
FAU - Martino, G
AU  - Martino G
FAU - Zardini, E
AU  - Zardini E
FAU - Desina, G
AU  - Desina G
FAU - Cosi, V
AU  - Cosi V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur Cytokine Netw
JT  - European cytokine network
JID - 9100879
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Methylprednisolone/*therapeutic use
MH  - Multiple Sclerosis/*blood/*cerebrospinal fluid/drug therapy
MH  - Receptors, Tumor Necrosis Factor/blood/*metabolism
MH  - Tumor Necrosis Factor-alpha/cerebrospinal fluid/*metabolism
EDAT- 1999/09/08 00:00
MHDA- 1999/09/08 00:01
CRDT- 1999/09/08 00:00
PHST- 1999/09/08 00:00 [pubmed]
PHST- 1999/09/08 00:01 [medline]
PHST- 1999/09/08 00:00 [entrez]
PST - ppublish
SO  - Eur Cytokine Netw. 1999 Sep;10(3):431-6.