PMID- 10477848
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20131121
IS  - 1074-3022 (Print)
IS  - 1074-3022 (Linking)
VI  - 5
IP  - 5
DP  - 1999 Sep
TI  - Encephalopathy associated with human herpesvirus 6 in a liver transplant 
      recipient.
PG  - 454-5
AB  - Recent reports have documented human herpesvirus 6 (HHV-6) as a cause of high 
      fever, bone marrow depression, and rash in liver transplant recipients in the 
      absence of another known pathogen. We describe a 49-year-old liver transplant 
      recipient who developed confusion, occipital headache, and involuntary movements 
      of the limbs 3 weeks after orthotopic liver transplantation. HHV-6 was detected 
      in the peripheral blood using a rapid culture assay. Examination of cerebrospinal 
      fluid by polymerase chain reaction for HHV-6 was also positive. No other 
      pathogens were identified. The patient improved after commencement of intravenous 
      ganciclovir therapy. This case suggests HHV-6 needs to be considered in the 
      differential diagnosis of unexplained confusion in liver transplant recipients.
FAU - Paterson, D L
AU  - Paterson DL
AD  - Veterans Affairs Medical Center, Pittsburgh, PA 15240, USA.
FAU - Singh, N
AU  - Singh N
FAU - Gayowski, T
AU  - Gayowski T
FAU - Carrigan, D R
AU  - Carrigan DR
FAU - Marino, I R
AU  - Marino IR
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Liver Transpl Surg
JT  - Liver transplantation and surgery : official publication of the American 
      Association for the Study of Liver Diseases and the International Liver 
      Transplantation Society
JID - 9502504
RN  - 0 (Antiviral Agents)
RN  - 0 (DNA, Viral)
RN  - P9G3CKZ4P5 (Ganciclovir)
SB  - IM
MH  - Antiviral Agents/administration & dosage/therapeutic use
MH  - Cerebrospinal Fluid/virology
MH  - DNA, Viral/analysis
MH  - Diagnosis, Differential
MH  - Encephalitis, Viral/diagnosis/drug therapy/*virology
MH  - Ganciclovir/administration & dosage/therapeutic use
MH  - Herpesviridae Infections/diagnosis/drug therapy/*virology
MH  - *Herpesvirus 6, Human/genetics
MH  - Humans
MH  - Injections, Intravenous
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Postoperative Complications/diagnosis/drug therapy/*virology
EDAT- 1999/09/09 00:00
MHDA- 1999/09/09 00:01
CRDT- 1999/09/09 00:00
PHST- 1999/09/09 00:00 [pubmed]
PHST- 1999/09/09 00:01 [medline]
PHST- 1999/09/09 00:00 [entrez]
AID - S152764659900091X [pii]
AID - 10.1002/lt.500050504 [doi]
PST - ppublish
SO  - Liver Transpl Surg. 1999 Sep;5(5):454-5. doi: 10.1002/lt.500050504.