PMID- 10478704
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20191103
IS  - 0736-0258 (Print)
IS  - 0736-0258 (Linking)
VI  - 16
IP  - 4
DP  - 1999 Jul
TI  - Epidemiology and evidence for morbidity of nonconvulsive status epilepticus.
PG  - 314-22; discussion 353
AB  - Convulsive status epilepticus (SE) is convincingly related to serious morbidity 
      and mortality and well recognized as a medical emergency, but prompt diagnosis 
      and treatment of patients with nonconvulsive status epilepticus (NCSE) is often 
      not emphasized because its consequences are thought to be benign. Nonconvulsive 
      status epilepticus has been considered a relatively benign entity because it does 
      not produce the adverse systemic consequences of convulsive status epilepticus, 
      such as hyperthermia, acidosis, hyperkalemia, pulmonary compromise, or 
      cardiovascular collapse. However, recent reports indicate that NCSE is not so 
      benign. There are two major forms of NCSE, absence status epilepticus and complex 
      partial status epilepticus. Typical absence status epilepticus does not appear to 
      have very serious consequences and may be a type of "inhibitory" seizure, but 
      complex partial status epilepticus has been associated with serious morbidity and 
      mortality. Despite not causing the systemic physiologic or metabolic derangements 
      seen with convulsive SE, complex partial status epilepticus is still associated 
      with the two other major factors correlated with poor outcomes in convulsive SE: 
      1) neuronal damage from abnormal electrical activity and 2) the interaction of 
      acute neurologic disorders, such as stroke, that may precipitate SE. Other 
      similar epileptiform encephalopathies such as "subclinical," 
      "electroencephalographic," "nontonic-clonic," and "subtle" SE have not been as 
      well studied as NCSE but pose similar issues. Early diagnosis and aggressive 
      intervention have proven the best means of averting adverse outcomes in patients 
      with convulsive SE. The diagnosis and treatment of NCSE, particularly complex 
      partial status epilepticus, merit similar emphasis and attention.
FAU - Krumholz, A
AU  - Krumholz A
AD  - Maryland Epilepsy Center, Department of Neurology, University of Maryland School 
      of Medicine, Baltimore 21201, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Clin Neurophysiol
JT  - Journal of clinical neurophysiology : official publication of the American 
      Electroencephalographic Society
JID - 8506708
SB  - IM
MH  - Humans
MH  - Incidence
MH  - Morbidity
MH  - Status Epilepticus/*complications/*epidemiology/mortality/physiopathology
RF  - 55
EDAT- 1999/09/09 00:00
MHDA- 1999/09/09 00:01
CRDT- 1999/09/09 00:00
PHST- 1999/09/09 00:00 [pubmed]
PHST- 1999/09/09 00:01 [medline]
PHST- 1999/09/09 00:00 [entrez]
AID - 10.1097/00004691-199907000-00003 [doi]
PST - ppublish
SO  - J Clin Neurophysiol. 1999 Jul;16(4):314-22; discussion 353. doi: 
      10.1097/00004691-199907000-00003.