PMID- 10479064
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20200106
IS  - 0736-5748 (Print)
IS  - 0736-5748 (Linking)
VI  - 17
IP  - 4
DP  - 1999 Jul
TI  - Distribution of BDNF, NT-3 and NT-4 in the developing auditory brainstem.
PG  - 285-94
AB  - This study describes the developmental expression of three neurotrophins, brain 
      derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3) and neurotrophin (NT-4) 
      in the rat auditory brain-stem using immunohistochemistry. At postnatal day 0 
      (PND 0), neurotrophins expression was virtually absent from all auditory nuclei 
      in the brainstem, even though some positive neurons were observed in the 
      mesencephalic trigeminal nucleus at this age. However, BDNF, NT-3 and NT-4 
      positive neurons were observed in most brainstem auditory nuclei by PND 6. At the 
      following stages, there was a general increase in the intensity of the 
      neurotrophins immunoreactivity and BDNF labeling was particularly prominent in 
      most cochlear nucleus neurons. A differential pattern of staining emerged in 
      cochlear nucleus subdivisions, with more intense staining present in the ventral 
      part. The superior olivary complex nuclei followed a similar pattern of BDNF 
      staining compared to the cochlear nucleus. In the adult, BDNF heavily labeled 
      most neurons of the superior olivary nuclei and moderately labeled neurons of the 
      inferior colliculus (IC). NT-3 and NT-4 showed a similar pattern of staining in 
      most auditory brainstem nuclei. The first staining was observed by PND 6 in some 
      neuronal cell bodies. NT-3 and NT-4 immunoreactivity increased in the following 
      stages and in the adult moderate labelings were observed in most neurons of the 
      cochlear nucleus, the superior olivary nuclei and the IC. These results show that 
      neurotrophins are expressed 1 week before the onset of hearing and the increase 
      of their expressions correlate with the appearance of sound-evoked activity in 
      the system. The temporal distribution of neurotrophins does not correlate with 
      neuronal birth, axonal outgrowth or the formation of connection in the auditory 
      structures, suggesting a role primarily in the maintenance and/ or modulation of 
      postnatal and adult functions.
FAU - Hafidi, A
AU  - Hafidi A
AD  - Unite INSERM 384, Faculte de Medecine, Clermont-Ferrand, France. 
      hafidi@cicsun.uni-bpclermont.fr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Aging/metabolism
MH  - Animals
MH  - Animals, Newborn/growth & development/*metabolism
MH  - Auditory Pathways/*metabolism
MH  - Brain Stem/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Immunohistochemistry
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
EDAT- 1999/09/09 00:00
MHDA- 1999/09/09 00:01
CRDT- 1999/09/09 00:00
PHST- 1999/09/09 00:00 [pubmed]
PHST- 1999/09/09 00:01 [medline]
PHST- 1999/09/09 00:00 [entrez]
AID - S0736-5748(99)00043-X [pii]
AID - 10.1016/s0736-5748(99)00043-x [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 1999 Jul;17(4):285-94. doi: 10.1016/s0736-5748(99)00043-x.