PMID- 10479455
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20161124
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 213
IP  - 2
DP  - 1999 Sep 15
TI  - NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation.
PG  - 378-89
AB  - Neurotrophins are key determinants for controlling the survival of peripheral 
      neurons during development. Brain-derived neurotrophic factor (BDNF) and 
      neurotrophin-4/5 (NT4/5) exert their action through a common trkB receptor but 
      independently support gustatory sensory neurons. To assess the role of NT4/5 
      during development, we examined the postnatal development and maintenance of 
      fungiform taste buds in mice carrying a deletion of NT4/5. The absence of NT4/5 
      results in embryonic deficits in gustatory innervation and a reduced number of 
      fungiform papillae at birth. No degenerative deficits of fungiform papillae were 
      observed for the first 3 weeks of postnatal development. However, these remaining 
      fungiform papillae were smaller in appearance and many did not contain taste 
      pores. By postnatal day 60, there was 63% decrease in the number of fungiform 
      papillae, and remaining papillae were smaller in size or modified into 
      filiform-like spines. These papillae had either no taste bud or a taste bud with 
      a reduced number of taste cells compared to controls. These findings demonstrate 
      that the NT4/5 gene functions in the maintenance of fungiform gustatory papillae 
      and raises the possibility for an earlier role in development.
CI  - Copyright 1999 Academic Press.
FAU - Liebl, D J
AU  - Liebl DJ
AD  - Center for Developmental Biology, University of Texas Southwestern Medical 
      Center, 6000 Harry Hines Boulevard, Dallas, Texas, 75235-9133, USA.
FAU - Mbiene, J P
AU  - Mbiene JP
FAU - Parada, L F
AU  - Parada LF
LA  - eng
GR  - R01 NS33199/NS/NINDS NIH HHS/United States
GR  - R03 DC03503/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 145172-44-7 (neurotrophin 5)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Embryonic and Fetal Development/physiology
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Mice
MH  - Microscopy, Electron, Scanning
MH  - Mutation
MH  - Nerve Growth Factors/*genetics
MH  - Taste Buds/*embryology/physiology/ultrastructure
MH  - Tongue/*embryology/innervation/physiology/ultrastructure
EDAT- 1999/09/10 00:00
MHDA- 1999/09/10 00:01
CRDT- 1999/09/10 00:00
PHST- 1999/09/10 00:00 [pubmed]
PHST- 1999/09/10 00:01 [medline]
PHST- 1999/09/10 00:00 [entrez]
AID - S0012-1606(99)99385-5 [pii]
AID - 10.1006/dbio.1999.9385 [doi]
PST - ppublish
SO  - Dev Biol. 1999 Sep 15;213(2):378-89. doi: 10.1006/dbio.1999.9385.