PMID- 10479648
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190831
IS  - 1079-5642 (Print)
IS  - 1079-5642 (Linking)
VI  - 19
IP  - 9
DP  - 1999 Sep
TI  - Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular 
      adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial 
      cells.
PG  - 2078-84
AB  - As distal targets and mediators of signal transduction pathways, activator 
      protein-1 (AP-1), c-Jun, and c-Fos are among the primary regulators of genes 
      involved in cell function, proliferation, and differentiation. By using 
      adenovirus-mediated gene transfer, we show that overexpression of AP-1 proteins 
      directly causes coinduction of gene expression of an adhesion molecule, 
      intercellular adhesion molecule-1 (ICAM-1), and a chemokine, monocyte 
      chemoattractant protein-1 (MCP-1), in human vascular endothelial cells (ECs). The 
      AP-1-induced gene expression occurs through a mechanism independent of nuclear 
      factor-kappaB. Because the induced expression of ICAM-1 and MCP-1 in ECs has been 
      implicated in endothelial activation and a number of important vascular 
      disorders, it is suggested that AP-1 activation may play an important role in the 
      pathogeneses of inflammation, angiogenesis, and atherogenesis.
FAU - Wang, N
AU  - Wang N
AD  - Division of Biomedical Sciences, University of California, Riverside 92521, USA.
FAU - Verna, L
AU  - Verna L
FAU - Hardy, S
AU  - Hardy S
FAU - Forsayeth, J
AU  - Forsayeth J
FAU - Zhu, Y
AU  - Zhu Y
FAU - Stemerman, M B
AU  - Stemerman MB
LA  - eng
SI  - GENBANK/U62024
GR  - HL43023/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Chemokine CCL2)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factor AP-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adenoviridae/*genetics
MH  - Binding Sites
MH  - Cells, Cultured
MH  - Chemokine CCL2/*genetics
MH  - Endothelium, Vascular/cytology/*physiology
MH  - *Gene Expression
MH  - Gene Transfer Techniques
MH  - Genetic Vectors
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*genetics
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic/physiology
MH  - Proto-Oncogene Proteins c-jun/*genetics
MH  - Transcription Factor AP-1/physiology
EDAT- 1999/09/10 00:00
MHDA- 1999/09/10 00:01
CRDT- 1999/09/10 00:00
PHST- 1999/09/10 00:00 [pubmed]
PHST- 1999/09/10 00:01 [medline]
PHST- 1999/09/10 00:00 [entrez]
AID - 10.1161/01.atv.19.9.2078 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2078-84. doi: 
      10.1161/01.atv.19.9.2078.