PMID- 10479698
OWN - NLM
STAT- MEDLINE
DCOM- 19991004
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 19
IP  - 18
DP  - 1999 Sep 15
TI  - Relative contribution of endogenous neurotrophins in hippocampal long-term 
      potentiation.
PG  - 7983-90
AB  - Recent evidence has shown that brain-derived neurotrophic factor (BDNF) is 
      involved in hippocampal long-term potentiation (LTP). Because the reagents used 
      in acute experiments react not only with BDNF but also with neurotrophin-4/5 
      (NT4/5) and neurotrophin-3 (NT3), we examined the involvement of these 
      neurotrophins in LTP using two highly specific, function-blocking monoclonal 
      antibodies against BDNF and NT3, as well as a TrkB-IgG fusion protein. Our 
      results show that NT3 antibodies did not have any effects on LTP. However, both 
      TrkB-IgG fusion proteins and BDNF antibody similarly reduced LTP, suggesting that 
      only BDNF but no other ligands of the TrkB-receptor are likely to be involved in 
      LTP induction. The reduction in LTP depended on the inducing stimuli and was only 
      observed with theta-burst stimulation (TBS) but not with tetanic stimulation. We 
      further observed that LTP was only reduced if BDNF was blocked before and during 
      TBS stimulation, and BDNF antibodies did not affect early or late stages of LTP 
      if they were applied 10, 30, or 60 min after TBS stimulation. These results point 
      toward a specific and unique role of endogenous BDNF but not of other 
      neurotrophins in the process of TBS-induced hippocampal LTP. Additionally, they 
      suggest that endogenous BDNF is required for a limited time period only shortly 
      before or around LTP induction but not during the whole process of LTP.
FAU - Chen, G
AU  - Chen G
AD  - Max-Planck-Institut fur Neurobiologie, D-82152 Munchen-Martinsried, Germany.
FAU - Kolbeck, R
AU  - Kolbeck R
FAU - Barde, Y A
AU  - Barde YA
FAU - Bonhoeffer, T
AU  - Bonhoeffer T
FAU - Kossel, A
AU  - Kossel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 145172-44-7 (neurotrophin 5)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*physiology
MH  - Electric Stimulation
MH  - Excitatory Postsynaptic Potentials
MH  - Hippocampus/*physiology
MH  - Immunoglobulin G
MH  - In Vitro Techniques
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Mice
MH  - Nerve Growth Factors/antagonists & inhibitors/*physiology
MH  - Neuronal Plasticity
MH  - Neurotrophin 3
MH  - Receptor Protein-Tyrosine Kinases/physiology
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/physiology
MH  - Recombinant Fusion Proteins/metabolism
MH  - Synaptic Transmission/*physiology
PMC - PMC6782442
EDAT- 1999/09/10 00:00
MHDA- 1999/09/10 00:01
PMCR- 2000/03/15
CRDT- 1999/09/10 00:00
PHST- 1999/09/10 00:00 [pubmed]
PHST- 1999/09/10 00:01 [medline]
PHST- 1999/09/10 00:00 [entrez]
PHST- 2000/03/15 00:00 [pmc-release]
AID - 3417 [pii]
AID - 10.1523/JNEUROSCI.19-18-07983.1999 [doi]
PST - ppublish
SO  - J Neurosci. 1999 Sep 15;19(18):7983-90. doi: 10.1523/JNEUROSCI.19-18-07983.1999.