PMID- 10482812
OWN - NLM
STAT- MEDLINE
DCOM- 19991020
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 839
IP  - 1
DP  - 1999 Aug 21
TI  - Effects of histamine on MK-801-induced memory deficits in radial maze performance 
      in rats.
PG  - 186-9
AB  - The effects of histamine on the spatial memory deficits induced by MK-801 were 
      investigated using the eight-arm radial maze paradigm in rats. 
      Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and 
      intraperitoneal (i.p.) injection of histidine improved the spatial memory 
      deficits induced by MK-801. Similar results were obtained with 
      2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant 
      effect. Based on these observations, it seems likely that the protective effect 
      of histamine on MK-801-induced spatial memory deficit is mediated by 
      H(1)-receptors.
FAU - Chen, Z
AU  - Chen Z
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama 
      University, Okayama, Japan.
FAU - Zhao, Q
AU  - Zhao Q
FAU - Sugimoto, Y
AU  - Sugimoto Y
FAU - Fujii, Y
AU  - Fujii Y
FAU - Kamei, C
AU  - Kamei C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Dizocilpine Maleate/*pharmacology
MH  - Excitatory Amino Acid Antagonists/*pharmacology
MH  - Histamine/*pharmacology
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory Disorders/chemically induced/*drug therapy
MH  - Psychomotor Performance/*drug effects
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/09/14 00:00
MHDA- 1999/09/14 00:01
CRDT- 1999/09/14 00:00
PHST- 1999/09/14 00:00 [pubmed]
PHST- 1999/09/14 00:01 [medline]
PHST- 1999/09/14 00:00 [entrez]
AID - S0006-8993(99)01739-4 [pii]
AID - 10.1016/s0006-8993(99)01739-4 [doi]
PST - ppublish
SO  - Brain Res. 1999 Aug 21;839(1):186-9. doi: 10.1016/s0006-8993(99)01739-4.