PMID- 10482869
OWN - NLM
STAT- MEDLINE
DCOM- 19991105
LR  - 20190905
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 86
IP  - 3
DP  - 1999 Sep 17
TI  - Impact on maternal parenting stress of receipt of genetic information regarding 
      risk of diabetes in newborn infants.
PG  - 219-26
AB  - Our objective was to investigate whether notification of high-risk status for 
      type 1 diabetes in newborn infants results in an increased maternal-parenting 
      stress level when compared with notification of low-risk status for type 1 
      diabetes. Maternal parenting stress level was assessed at 5-7 weeks postpartum 
      (baseline) and was reassessed 4-5 months after parents were informed of their 
      newborn infants' genetic screening results (follow-up). Parenting stress level 
      was measured using the total stress score (TSS) of the Parenting Stress 
      Index/Short Form. The outcome variable, change in TSS, was calculated by 
      subtracting the baseline TSS from the follow-up TSS. Demographic variables such 
      as maternal race, maternal age, maternal education level, maternal marital 
      status, child's birth order, and total family income were assessed through a 
      structured phone interview at the time of baseline assessment. The risk factor of 
      interest was the child's human leukocyte antigen (HLA) status for type 1 
      diabetes, i.e., whether child was at a high or moderate (combined into "high") 
      genetic risk or at a low genetic risk for type 1 diabetes. A sample of 88 mothers 
      (23 with a high-risk child and 65 with a low-risk child) was evaluated. Baseline 
      median TSSs were 65 and 74 for mothers of low-risk infants and mothers of 
      high-risk infants, respectively. Both groups' median TSS decreased between 
      baseline and follow-up. No significant differences were found between change in 
      TSS and maternal age, race, education level, marital status, total family income, 
      or child's birth order. Although the median decrease in TSS was smaller in 
      mothers with a high-risk child when compared with mothers of a low-risk child, 
      this difference was not statistically significant. We did not find an association 
      between newborn's HLA status and change in maternal TSS. The results of this 
      study suggest that notification of high-risk status for type 1 diabetes in 
      newborn infants may not result in an increased level of parenting stress among 
      mothers.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Yu, M S
AU  - Yu MS
AD  - Department of Preventive Medicine and Biometrics, University of Colorado Health 
      Sciences Center, Denver, Colorado 80262, USA.
FAU - Norris, J M
AU  - Norris JM
FAU - Mitchell, C M
AU  - Mitchell CM
FAU - Butler-Simon, N
AU  - Butler-Simon N
FAU - Groshek, M
AU  - Groshek M
FAU - Follansbee, D
AU  - Follansbee D
FAU - Erlich, H
AU  - Erlich H
FAU - Rewers, M
AU  - Rewers M
FAU - Klingensmith, G J
AU  - Klingensmith GJ
LA  - eng
GR  - FM01RR00069/RR/NCRR NIH HHS/United States
GR  - R01 DK-32493/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 1/*genetics/immunology/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Counseling
MH  - *Genetic Testing
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - *Maternal Behavior
MH  - Risk Factors
MH  - *Stress, Psychological
MH  - Surveys and Questionnaires
EDAT- 1999/09/14 00:00
MHDA- 1999/09/14 00:01
CRDT- 1999/09/14 00:00
PHST- 1999/09/14 00:00 [pubmed]
PHST- 1999/09/14 00:01 [medline]
PHST- 1999/09/14 00:00 [entrez]
AID - 10.1002/(SICI)1096-8628(19990917)86:3<219::AID-AJMG5>3.0.CO;2-7 [pii]
AID - 10.1002/(sici)1096-8628(19990917)86:3<219::aid-ajmg5>3.0.co;2-7 [doi]
PST - ppublish
SO  - Am J Med Genet. 1999 Sep 17;86(3):219-26. doi: 
      10.1002/(sici)1096-8628(19990917)86:3<219::aid-ajmg5>3.0.co;2-7.