PMID- 10483238
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 57
IP  - 8
DP  - 1999 Aug
TI  - [The linkage of the major histocompatibility complex to autoimmune thyroid 
      diseases].
PG  - 1710-5
AB  - To investigate the association between human leukocyte antigen (HLA) and 
      development of autoimmune thyroid diseases such as Graves' disease (GD), 
      Hashimoto's thyroiditis (HT), and Graves' disease patients with undetectable 
      TSH-binding inhibitor immunoglobulin (TBII-negative GD), HLA typing was done. 1. 
      We previously reported increased frequencies of HLA-A2 and DPB1*0501 in 
      TBII-positive GD patients, 2. significantly increased frequencies of HLA-A2 and 
      DPB4*0101 in patients with HT, 3. more TBII-negative GD patients having both 
      HLA-B46 and DPB1*0202 than those having each allele alone, suggesting that these 
      2 alleles may play a synergistic role in controlling the susceptibility to 
      TBII-negative GD, and 4. contrarily that the frequencies of DQA1*0102 in HT 
      patients and of DQB1*0501 in GD patients were significantly decreased, suggesting 
      that DQA1*0102 and DQB1*0501 might confer resistance to the development of HT and 
      GD.
FAU - Tamai, H
AU  - Tamai H
AD  - Kuma Hospital.
FAU - Matsubayashi, S
AU  - Matsubayashi S
FAU - Kimura, A
AU  - Kimura A
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Female
MH  - *Genetic Linkage
MH  - Humans
MH  - Major Histocompatibility Complex/*genetics/immunology
MH  - Male
MH  - Thyroid Diseases/*genetics/immunology
EDAT- 1999/09/14 00:00
MHDA- 1999/09/14 00:01
CRDT- 1999/09/14 00:00
PHST- 1999/09/14 00:00 [pubmed]
PHST- 1999/09/14 00:01 [medline]
PHST- 1999/09/14 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1999 Aug;57(8):1710-5.