PMID- 10483242
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20151119
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 57
IP  - 8
DP  - 1999 Aug
TI  - [Immunoregulatory genes in autoimmune thyroid disease].
PG  - 1737-42
AB  - Autoimmune thyroid diseases (AITD) has a strong genetic basis. Although several 
      candidate genes have been studied, the AITD causing genes are still unknown. 
      Major candidate immune regulatory genes include human leukocyte antigen (HLA) 
      gene, Ig heavy chain genes, T cell receptor genes, IL-1 receptor antagonist gene, 
      IL-1 alpha gene and cytotoxic T lymphocyte antigen-4 (CTLA-4) gene. The relation 
      between HLA and AITD has extensively been studied. In addition, polymorphism of 
      the 3'-untranslated region and codon 17 of the CTLA-4 gene has been reported to 
      associate positively with AITD. However, no linkage analyses have showed positive 
      relation between AITD and these candidate genes except for HLA.
FAU - Gemma, R
AU  - Gemma R
AD  - Department of Internal Medicine, Hamamatsu University School of Medicine.
FAU - Suda, T
AU  - Suda T
FAU - Nakamura, H
AU  - Nakamura H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Immunoconjugates)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Receptors, Interleukin-1)
RN  - 7D0YB67S97 (Abatacept)
SB  - IM
MH  - Abatacept
MH  - Antigens, CD
MH  - Antigens, Differentiation/genetics
MH  - Autoimmune Diseases/*genetics
MH  - CTLA-4 Antigen
MH  - Genes, T-Cell Receptor
MH  - Humans
MH  - *Immunoconjugates
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Receptors, Interleukin-1/antagonists & inhibitors
MH  - Thyroid Diseases/*genetics
RF  - 20
EDAT- 1999/09/14 00:00
MHDA- 1999/09/14 00:01
CRDT- 1999/09/14 00:00
PHST- 1999/09/14 00:00 [pubmed]
PHST- 1999/09/14 00:01 [medline]
PHST- 1999/09/14 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1999 Aug;57(8):1737-42.