PMID- 10484503
OWN - NLM
STAT- MEDLINE
DCOM- 19991018
LR  - 20181005
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 277
IP  - 3
DP  - 1999 Sep
TI  - Use of recombinant human soluble TNF receptor in anorectic tumor-bearing rats.
PG  - R850-5
LID - 10.1152/ajpregu.1999.277.3.R850 [doi]
AB  - With progression of tumor growth, rats demonstrate anorexia and reduced food 
      intake, a function of meal number and meal size. Tumor necrosis factor-alpha 
      (TNF-alpha), a recognized anorectic agent, reacts with two different receptors 
      (type I: 55 kDa; type II: 75 kDa). We used a dimeric, pegylated 55-kDa TNF 
      receptor construct to test its effects on food intake, meal number, and meal 
      size, which were continuously measured with a rat eater meter in 16 Fischer 344 
      male rats injected with 10(6) viable methylcholanthrene cells. When anorexia 
      developed, rats received a subcutaneous injection of either 0.25 mg/kg body wt of 
      soluble TNF receptor construct (study) or vehicle (tumor-bearing control). Before 
      TNF inhibitor injection, no differences were observed in food intake, meal 
      number, or meal size between the two groups. After the TNF inhibitor injection, 
      study vs. control rats significantly improved food intake as a result of an 
      increase in meal number and meal size. Rats also showed a significant improvement 
      in body weight. These data suggest that TNF-alpha, in addition to other 
      cytokines, contributes to the anorexia of tumor growth, probably mediated via the 
      hypothalamus.
FAU - Torelli, G F
AU  - Torelli GF
AD  - Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University 
      Hospital, State University of New York Health Science Center, New York, NY 13210, 
      USA.
FAU - Meguid, M M
AU  - Meguid MM
FAU - Moldawer, L L
AU  - Moldawer LL
FAU - Edwards, C K 3rd
AU  - Edwards CK 3rd
FAU - Kim, H J
AU  - Kim HJ
FAU - Carter, J L
AU  - Carter JL
FAU - Laviano, A
AU  - Laviano A
FAU - Rossi Fanelli, F
AU  - Rossi Fanelli F
LA  - eng
GR  - 70239/PHS HHS/International
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Anorexia/drug therapy/*physiopathology
MH  - Eating/drug effects
MH  - Humans
MH  - Male
MH  - Neoplasms, Experimental/*physiopathology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Tumor Necrosis Factor/administration & dosage/*physiology
MH  - Recombinant Proteins/administration & dosage
MH  - Tumor Necrosis Factor-alpha/physiology
EDAT- 1999/09/14 09:00
MHDA- 1999/09/14 09:01
CRDT- 1999/09/14 09:00
PHST- 1999/09/14 09:00 [pubmed]
PHST- 1999/09/14 09:01 [medline]
PHST- 1999/09/14 09:00 [entrez]
AID - 10.1152/ajpregu.1999.277.3.R850 [doi]
PST - ppublish
SO  - Am J Physiol. 1999 Sep;277(3):R850-5. doi: 10.1152/ajpregu.1999.277.3.R850.