PMID- 10485372
OWN - NLM
STAT- MEDLINE
DCOM- 19991014
LR  - 20191103
IS  - 0902-0063 (Print)
IS  - 0902-0063 (Linking)
VI  - 13
IP  - 4
DP  - 1999 Aug
TI  - Clinical risk factors for recurrence of IgA nephropathy.
PG  - 313-7
AB  - No clinical risk factors for recurrence of immunoglobulin A (IgA) nephropathy in 
      kidney transplants have been defined. This is a single-centre retrospect analysis 
      of recurrence in 104 first kidney transplant patients with biopsy-verified IgA 
      nephropathy. Fifty patients had living donors. All but an identical twin were 
      treated with cyclosporin A. The median follow-up time was 5 yr. Graft biopsies 
      had been obtained from 35 grafts later than 6 months after transplantation, due 
      to deteriorating graft function or gross proteinuria. Thirteen biopsies showed 
      mesangial glomerulopathy proliferative in eleven cases with IgA deposits. 
      Recurrence caused failure of six grafts. Eleven grafts with recurrence were from 
      living donors (p = 0.005). No specific human leukocyte antigen (HLA) was 
      identified as a risk factor. Known duration of original disease until end-stage 
      renal failure was significantly shorter in patients with recurrence (median 5 yr, 
      range 0-25 yr) compared with those without (median of 10 yr, range of 0-37 yr) (p 
      = 0.015). Cumulative graft survival was not reduced in living versus cadaveric 
      donor recipients.
FAU - Freese, P
AU  - Freese P
AD  - Transplant Unit, Sahlgrenska Universitetssjukhuset, Goteborg, Sweden.
FAU - Svalander, C
AU  - Svalander C
FAU - Norden, G
AU  - Norden G
FAU - Nyberg, G
AU  - Nyberg G
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biopsy
MH  - Child
MH  - Female
MH  - Glomerulonephritis, IGA/etiology/pathology/*surgery
MH  - Graft Survival
MH  - Humans
MH  - Kidney/pathology
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 1999/09/15 00:00
MHDA- 1999/09/15 00:01
CRDT- 1999/09/15 00:00
PHST- 1999/09/15 00:00 [pubmed]
PHST- 1999/09/15 00:01 [medline]
PHST- 1999/09/15 00:00 [entrez]
AID - 10.1034/j.1399-0012.1999.130406.x [doi]
PST - ppublish
SO  - Clin Transplant. 1999 Aug;13(4):313-7. doi: 10.1034/j.1399-0012.1999.130406.x.