PMID- 10486398
OWN - NLM
STAT- MEDLINE
DCOM- 19991201
LR  - 20190501
IS  - 0022-3050 (Print)
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 67
IP  - 4
DP  - 1999 Oct
TI  - Effect of interstimulus interval on visual P300 in Parkinson's disease.
PG  - 497-503
AB  - OBJECTIVE: Visual event related potentials (ERPs) were studied during an oddball 
      paradigm, to testify whether cognitive slowing in Parkinson's disease exists and 
      to investigate whether cognitive information processing can be influenced by 
      different interstimulus intervals (ISIs) of an oddball task in patients with 
      Parkinson's disease and normal subjects. METHODS: ERPs and reaction time were 
      measured in 38 non-demented patients with Parkinson's disease and 24 healthy 
      elderly subjects. A visual oddball paradigm was employed to evoke ERPs, at three 
      different interstimulus (ISI) intervals: ISI(S), 1600 ms; ISI(M), 3100 ms; and 
      ISI(L), 5100 ms. The effect of ISIs on ERPs and reaction time was investigated. 
      RESULTS: Compared with the normal subjects, P300 latency at Cz and Pz was 
      significantly delayed after rare target stimuli in patients with Parkinson's 
      disease only at ISI(L). Reaction time was prolonged in patients at all the three 
      ISIs, compared with the normal controls. There was also significantly delayed 
      N200 and reduced P300 amplitude at Cz and/or Pz to rare non-target stimuli in 
      patients at the three ISIs, compared with the normal controls. During rare target 
      visual stimulation, P300 latency and reaction time in the patients with 
      Parkinson's disease and reaction time in the normal subjects were gradually 
      prolonged as the ISI increased. CONCLUSION: Prolonged N200 latency to rare 
      non-target stimuli might indicate that automatic cognitive processing was slowed 
      in Parkinson's disease. Cognitive processing reflected by P300 latency to rare 
      target stimuli was influenced by longer ISI in patients with Parkinson's disease.
FAU - Wang, L
AU  - Wang L
AD  - Department of Neurology, Yokohama City University School of Medicine, 3-9 
      Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
FAU - Kuroiwa, Y
AU  - Kuroiwa Y
FAU - Kamitani, T
AU  - Kamitani T
FAU - Takahashi, T
AU  - Takahashi T
FAU - Suzuki, Y
AU  - Suzuki Y
FAU - Hasegawa, O
AU  - Hasegawa O
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Brain/*physiopathology
MH  - Electroencephalography
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*physiopathology
MH  - Photic Stimulation
MH  - Reaction Time/physiology
PMC - PMC1736567
EDAT- 1999/09/16 00:00
MHDA- 1999/09/16 00:01
PMCR- 2002/10/01
CRDT- 1999/09/16 00:00
PHST- 1999/09/16 00:00 [pubmed]
PHST- 1999/09/16 00:01 [medline]
PHST- 1999/09/16 00:00 [entrez]
PHST- 2002/10/01 00:00 [pmc-release]
AID - 10.1136/jnnp.67.4.497 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):497-503. doi: 
      10.1136/jnnp.67.4.497.