PMID- 10488482
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20131121
IS  - 0029-5566 (Print)
IS  - 0029-5566 (Linking)
VI  - 38
IP  - 5
DP  - 1999
TI  - [Can immunoradiometric measurement of thyrotropin (TSH) in human serum compete 
      with a luminometric assay?].
PG  - 150-5
AB  - The development of highly sensitive, nonradioimmunometric assays for the 
      measurement of thyrotropin (TSH) during the last few years have improved the 
      measurement of low TSH values and thus benefit the diagnosis of thyroid function 
      disorders. These third or fourth generation assays are especially popular in 
      laboratories not accustomed to the use of radioactive tracers and can be easily 
      automatized. AIM: This study investigates whether these new assays provide an 
      advantage in routine diagnosis of thyroid disorders. METHODS: TSH was measured in 
      150 patients with various thyroid pathology using an immunoradiometric assay 
      (IRMA) as well as a highly sensitive luminometric assay (LUMI), both by 
      B.R.A.H.M.S. Diagnostica. We used the current modern IRMA (available since 1997) 
      TSH was below 0.4 mU/l, between 0.4 and 4.0 mU/l, and above 4.0 mU/l in a third 
      of the patients in each group, respectively. RESULTS: As expected the results 
      obtained with LUMI and IRMA correlated well for TSH values above 0.1 mU/l and 
      less well between 0.1 and 0.01 mU/l. There was no correlation between the two 
      types of assay at TSH concentrations below 0.01 mU/l. This shows that 
      measurements using both types of assay become increasingly less precise below 0.1 
      mU/l. CONCLUSION: Both types of assay gave an identical estimate of thyroid 
      function in every single patient. Use of the LUMI did not give additional 
      information leading to a change in patient management. Therefore, TSH measurement 
      using IRMA does still meet today's routine clinical requirements.
FAU - Zophel, K
AU  - Zophel K
AD  - Klinik und Poliklinik fur Nuklearmedizin, Universitatsklinikum Carl Gustav Carus 
      der Technischen Universitat Dresden, Deutschland. kzophel@rcs.urz.tu-dresden.de
FAU - Pinkert, J
AU  - Pinkert J
FAU - Wunderlich, G
AU  - Wunderlich G
FAU - Gruning, T
AU  - Gruning T
FAU - Franke, W G
AU  - Franke WG
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Ist die immunradiometrische Bestimmung von Thyreotropin (TSH) im Humanserum einem 
      Lumineszenzassay unterlegen?
PL  - Germany
TA  - Nuklearmedizin
JT  - Nuklearmedizin. Nuclear medicine
JID - 7609387
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Automation
MH  - Humans
MH  - Hyperthyroidism/blood/diagnosis
MH  - Immunoradiometric Assay/methods
MH  - Luminescent Measurements
MH  - Quality Control
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Thyroid Diseases/*blood/*diagnosis
MH  - Thyrotropin/*blood
MH  - Thyroxine/blood
MH  - Triiodothyronine/blood
EDAT- 1999/09/17 00:00
MHDA- 1999/09/17 00:01
CRDT- 1999/09/17 00:00
PHST- 1999/09/17 00:00 [pubmed]
PHST- 1999/09/17 00:01 [medline]
PHST- 1999/09/17 00:00 [entrez]
PST - ppublish
SO  - Nuklearmedizin. 1999;38(5):150-5.