PMID- 10488751
OWN - NLM
STAT- MEDLINE
DCOM- 20000131
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 54
IP  - 2
DP  - 1999 Aug
TI  - No association with HLA-DQB1 in European Caucasians with early-onset 
      periodontitis.
PG  - 205-7
AB  - Periodontitis is a chronic inflammatory disease of the supporting tissues of the 
      teeth that may ultimately result in tooth loss. The human leukocyte antigen (HLA) 
      complex plays an important role in immune responsiveness and may be involved in 
      antigen recognition of periodontal pathogens. A recent report of a Japanese 
      population found an association between an atypical BamHI site in the HLA-DQB1 
      gene and a severe form of early-onset periodontitis (EOP). The aim of the present 
      study was to test for the existence of the site in a European Caucasian EOP 
      population using polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) analysis. No statistically significant differences were 
      found between the patients and controls with regard to the presence of the BamHI 
      site. It was concluded that this lack of association could reflect racial genetic 
      variation in HLA allelic frequencies.
FAU - Hodge, P J
AU  - Hodge PJ
AD  - Periodontal and Oral Immunology, Research Group, Glasgow Dental Hospital and 
      School, UK. pjh@hodgeqc.freeserve.co.uk
FAU - Riggio, M P
AU  - Riggio MP
FAU - Kinane, D F
AU  - Kinane DF
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Alleles
MH  - Europe
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Periodontitis/*genetics/*immunology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - White People
EDAT- 1999/09/17 00:00
MHDA- 1999/09/17 00:01
CRDT- 1999/09/17 00:00
PHST- 1999/09/17 00:00 [pubmed]
PHST- 1999/09/17 00:01 [medline]
PHST- 1999/09/17 00:00 [entrez]
AID - 10.1034/j.1399-0039.1999.540215.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1999 Aug;54(2):205-7. doi: 10.1034/j.1399-0039.1999.540215.x.