PMID- 10491573
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20051117
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 58
IP  - 1
DP  - 1999 Oct 1
TI  - Neurotrophins and hippocampal synaptic transmission and plasticity.
PG  - 76-87
AB  - Neurotrophins are traditionally thought to be secretory proteins that regulate 
      long-term survival and differentiation of neurons. Recent studies have revealed a 
      previously unexpected role for neurotrophins in synaptic development and 
      plasticity in diverse neuronal populations. In this review, we focus on the 
      synaptic function of brain-derived neurotrophic factor (BDNF) in the hippocampus. 
      Although a variety of in vitro experiments have shown the ability of BDNF to 
      acutely modulate synaptic transmission, whether BDNF truly potentiates basal 
      synaptic transmission in hippocampal neurons remains controversial. More 
      consistent evidence has been obtained for the role of BDNF in long-term 
      potentiation (LTP), a cellular model for learning and memory. BDNF also 
      potentiates high frequency transmission by modulating the number of docked 
      vesicles and the levels of the vesicle protein synaptobrevin and synaptophysin at 
      the CA1 synapses. Both pre- and postsynaptic effects of BDNF have been 
      demonstrated. Recent studies have begun to address the role of BDNF in late-phase 
      LTP and in the development of hippocampal circuit. BDNF and other neurotrophins 
      may represent a new class of neuromodulators that regulate neuronal connectivity 
      and synaptic efficacy. J. Neurosci. Res. 58:76-87, 1999. Published 1999 
      Wiley-Liss, Inc.
FAU - Lu, B
AU  - Lu B
AD  - Unit on Synapse Development and Plasticity, Laboratory of Developmental 
      Neurobiology, NICHD, NIH, Bethesda, Maryland 20892-4480, USA. lub@codon.nih.gov
FAU - Chow, A
AU  - Chow A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (R-SNARE Proteins)
RN  - 0 (Synaptophysin)
SB  - IM
MH  - Animals
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Long-Term Potentiation/physiology
MH  - Membrane Proteins/physiology
MH  - Nerve Tissue Proteins/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - R-SNARE Proteins
MH  - Synapses/*physiology
MH  - Synaptic Transmission/*physiology
MH  - Synaptophysin/physiology
RF  - 130
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - 10.1002/(SICI)1097-4547(19991001)58:1<76::AID-JNR8>3.0.CO;2-0 [pii]
PST - ppublish
SO  - J Neurosci Res. 1999 Oct 1;58(1):76-87.