PMID- 10491575
OWN - NLM
STAT- MEDLINE
DCOM- 19991104
LR  - 20061115
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 58
IP  - 1
DP  - 1999 Oct 1
TI  - Immediate early gene transcription and synaptic modulation.
PG  - 96-106
AB  - Long-term changes in gene expression appear to be critical to the formation of 
      memory, but little is known about its stimulus- transcription coupling. Numerous 
      studies in the last decade, by focusing on unraveling this signal transduction 
      pathway, have investigated the potential role of the immediate-early genes in 
      this process. The krox family of immediate-early gene proteins are of particular 
      interest because they may be involved in stabilizing the synaptic modifications 
      that underlie hippocampal long-term potentiation (LTP). A potential upstream 
      mediator of krox induction is cyclic AMP-responsive element binding protein 
      (CREB), a posttranslationally activated transcription factor that has been 
      implicated in numerous memory paradigms. In this study we investigated whether 
      the activation of CREB by phosphorylation may have a role in the development of 
      rat perforant- path-stimulated LTP and associated dentate granule cell krox-24 
      mRNA expression. Contrary to what was expected, we failed to show any difference 
      in the levels of phosphorylated CREB after LTP or following endogenous synaptic 
      facilitation stimulated by novelty. Using these same model systems we also 
      investigated the protein levels of brain- derived neurotrophic factor (BDNF), 
      another immediate-early gene that is induced following a durable form of LTP. 
      However, BDNF protein was not induced within the hippocampus after LTP and was 
      transiently decreased following novel environmental stimulation.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Walton, M
AU  - Walton M
AD  - Department of Pharmacology, Faculty of Medicine and Health Science, University of 
      Auckland, Auckland, New Zealand.
FAU - Henderson, C
AU  - Henderson C
FAU - Mason-Parker, S
AU  - Mason-Parker S
FAU - Lawlor, P
AU  - Lawlor P
FAU - Abraham, W C
AU  - Abraham WC
FAU - Bilkey, D
AU  - Bilkey D
FAU - Dragunow, M
AU  - Dragunow M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (EGR1 protein, human)
RN  - 0 (Early Growth Response Protein 1)
RN  - 0 (Egr1 protein, rat)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/physiology
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - DNA-Binding Proteins/genetics
MH  - Early Growth Response Protein 1
MH  - Gene Expression Regulation
MH  - *Genes, Immediate-Early
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Immediate-Early Proteins/*genetics
MH  - Long-Term Potentiation/*physiology
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Synapses/*physiology
MH  - Transcription Factors/genetics
MH  - *Transcription, Genetic
RF  - 99
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - 10.1002/(SICI)1097-4547(19991001)58:1<96::AID-JNR10>3.0.CO;2-N [pii]
PST - ppublish
SO  - J Neurosci Res. 1999 Oct 1;58(1):96-106.