PMID- 10492009
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20181113
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 6
IP  - 3
DP  - 1999 May-Jun
TI  - Transgenic brain-derived neurotrophic factor modulates a developing cerebellar 
      inhibitory synapse.
PG  - 276-83
AB  - Brain-derived neurotrophic factor (BDNF) has been shown to promote synapse 
      formation and maturation in neurons of many brain regions, including inhibitory 
      synapses. In the cerebellum, the Golgi cell-granule cell GABAergic synaptic 
      responses undergo developmental transition from slow-decaying to fast-decaying 
      kinetics, which parallels a developmental increase of GABA(A) receptor alpha6 
      subunit expression in the cerebellar granule cells. In culture, BDNF accelerates 
      the expression of GABA(A) receptor alpha6 subunit expression in granule cells. 
      Here we examined synaptic GABA(A) response kinetics in BDNF transgenic mice. The 
      mutant mouse, which carries a BDNF transgene driven by a beta-actin promoter, 
      overexpresses BDNF (two- to fivefold increase compared with wild types) in all 
      brain regions. Recordings of the spontaneous GABA(A) responses indicate that the 
      decay time constant of the GABAergic responses decreases during early postnatal 
      development; this transition is accelerated in the BDNF transgenic mouse. The 
      amplitude of the spontaneous GABA(A) responses was also larger in the transgenic 
      mouse than in the wild-type mouse. However, the frequency of the spontaneous 
      GABA(A) responses were not different between the two groups. Our results suggest 
      that BDNF may modulate GABAergic synapse maturation in the cerebellum.
FAU - Bao, S
AU  - Bao S
AD  - Neuroscience Program, University of Southern California, Los Angeles 90089-2520, 
      USA.
FAU - Chen, L
AU  - Chen L
FAU - Qiao, X
AU  - Qiao X
FAU - Thompson, R F
AU  - Thompson RF
LA  - eng
GR  - 5P20-MH52194/MH/NIMH NIH HHS/United States
GR  - AG-14751/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Blotting, Northern
MH  - Brain-Derived Neurotrophic Factor/genetics/*physiology
MH  - Cerebellum/growth & development/*physiology
MH  - Electrophysiology
MH  - Excitatory Postsynaptic Potentials/drug effects/physiology
MH  - In Situ Hybridization
MH  - In Vitro Techniques
MH  - Mice
MH  - Mice, Transgenic
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Synapses/*physiology
PMC - PMC311309
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
PMCR- 2000/05/01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
PHST- 2000/05/01 00:00 [pmc-release]
PST - ppublish
SO  - Learn Mem. 1999 May-Jun;6(3):276-83.