PMID- 10492010
OWN - NLM
STAT- MEDLINE
DCOM- 19991019
LR  - 20181113
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 6
IP  - 3
DP  - 1999 May-Jun
TI  - BDNF regulates the intrinsic excitability of cortical neurons.
PG  - 284-91
AB  - Neocortical pyramidal neurons respond to prolonged activity blockade by 
      modulating their balance of inward and outward currents to become more sensitive 
      to synaptic input, possibly as a means of homeostatically regulating firing rates 
      during periods of intense change in synapse number or strength. Here we show that 
      this activity-dependent regulation of intrinsic excitability depends on the 
      neurotrophin brain-derived neurotrophic factor (BDNF). In experiments on rat 
      visual cortical cultures, we found that exogenous BDNF prevented, and a TrkB-IgG 
      fusion protein reproduced, the change in pyramidal neuron excitability produced 
      by activity blockade. Most of these effects were also observed in bipolar 
      interneurons, indicating a very general role for BDNF in regulating neuronal 
      excitability. Moreover, earlier work has demonstrated that BDNF mediates a 
      different kind of homeostatic plasticity present in these same cultures: scaling 
      of the quantal amplitude of AMPA-mediated synaptic inputs up or down as a 
      function of activity. Taken together, these results suggest that BDNF may be the 
      signal controlling a coordinated regulation of synaptic and intrinsic properties 
      aimed at allowing cortical networks to adapt to long-lasting changes in activity.
FAU - Desai, N S
AU  - Desai NS
AD  - Department of Biology and Center for Complex Systems, Brandeis University, 
      Waltham, Massachusetts 02454-9110, USA.
FAU - Rutherford, L C
AU  - Rutherford LC
FAU - Turrigiano, G G
AU  - Turrigiano GG
LA  - eng
GR  - K02 NS01893/NS/NINDS NIH HHS/United States
GR  - R01 NS36853/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4368-28-9 (Tetrodotoxin)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/physiology
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Cerebral Cortex/cytology/*physiology
MH  - Electrophysiology
MH  - In Vitro Techniques
MH  - Membrane Potentials/physiology
MH  - Neuronal Plasticity/drug effects
MH  - Neurons/metabolism/*physiology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Synapses/physiology
MH  - Tetrodotoxin/pharmacology
MH  - Visual Cortex/cytology/physiology
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology
PMC - PMC311300
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
PMCR- 2000/05/01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
PHST- 2000/05/01 00:00 [pmc-release]
PST - ppublish
SO  - Learn Mem. 1999 May-Jun;6(3):284-91.