PMID- 10492393
OWN - NLM
STAT- MEDLINE
DCOM- 19991022
LR  - 20190921
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 21
IP  - 5
DP  - 1999 Sep-Oct
TI  - In utero alcohol and postnatal methylphenidate: locomotion and dopamine 
      receptors.
PG  - 587-93
AB  - Prenatal alcohol exposure can cause central nervous system abnormalities and 
      dysfunction referred to as Alcohol-Related Neurodevelopmental Disorder (ARND). 
      Repeated intermittent methylphenidate (Ritalin) was used as a 
      psychopharmacological challenge to reveal functional alterations in dopamine 
      binding sites in rats exposed prenatally to alcohol. Pregnant Long-Evans dams 
      were intubated with 0, 3, or 5 g/kg/day of alcohol from gestational day (GD) 8 to 
      GD20. Adult offspring received repeated intraperitoneal injections of 0, 4, or 8 
      mg/kg of methylphenidate (MET), and were tested periodically for locomotor 
      activity. Autoradiographic assessment of dopamine D1 and D2 receptors binding 
      were visualized using [3H]SCH 23390 and [3H]raclopride, respectively. Prenatal 
      alcohol did not produce significant dose-dependent effects on adult locomotor 
      activity. Repeated MET injections produced dose-dependent sensitization of 
      locomotor activity in all groups. The 3-g/kg prenatal alcohol group had a 
      significantly decreased number of dopamine D2 binding sites within the dorsal and 
      ventral striatum. This effect was reversed by MET. The neural changes detected in 
      the lower alcohol group may indicate persistent changes within the dopaminergic 
      system due to prenatal alcohol exposure.
FAU - Randall, S
AU  - Randall S
AD  - Department of Psychology, Wayne State University, Detroit, MI 48201, USA.
FAU - Hannigan, J H
AU  - Hannigan JH
LA  - eng
GR  - AA06721/AA/NIAAA NIH HHS/United States
GR  - AA07606/AA/NIAAA NIH HHS/United States
GR  - GM08167/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - 0 (Receptors, Dopamine D1)
RN  - 0 (Receptors, Dopamine D2)
RN  - 10028-17-8 (Tritium)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - 3K9958V90M (Ethanol)
RN  - 430K3SOZ7G (Raclopride)
SB  - IM
MH  - Animals
MH  - Benzazepines/metabolism
MH  - Binding Sites
MH  - Binding, Competitive/drug effects
MH  - Brain/drug effects/metabolism
MH  - Dopamine Uptake Inhibitors/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*adverse effects
MH  - Female
MH  - Male
MH  - Methylphenidate/*pharmacology
MH  - Motor Activity/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Raclopride/metabolism
MH  - Radioligand Assay
MH  - Rats
MH  - Rats, Long-Evans
MH  - Receptors, Dopamine D1/drug effects/metabolism
MH  - Receptors, Dopamine D2/drug effects/metabolism
MH  - Tritium
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - S0892-0362(99)00017-3 [pii]
AID - 10.1016/s0892-0362(99)00017-3 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1999 Sep-Oct;21(5):587-93. doi: 
      10.1016/s0892-0362(99)00017-3.