PMID- 10494147
OWN - NLM
STAT- MEDLINE
DCOM- 19991018
LR  - 20190513
IS  - 0449-3060 (Print)
IS  - 0449-3060 (Linking)
VI  - 40
IP  - 2
DP  - 1999 Jun
TI  - Chromosomal instability in acute myelocytic leukemia and myelodysplastic syndrome 
      patients among atomic bomb survivors.
PG  - 159-67
AB  - To clarify the mechanism of leukemogenesis in atomic bomb survivors, leukemic 
      cells were investigated using fluorescence in situ hybridization (FISH) analysis 
      on the basis of conventional G-banding in patients with a history of radiation 
      exposure and also in de novo patients. Conventional G-banding showed higher 
      incidences (p < 0.005) of structural and numerical abnormalities without any 
      specific types of chromosome aberrations in the group exposed to a dose of more 
      than one Gy, compared to the non-exposed group. FISH analysis revealed 
      significantly higher incidences (P < 0.05) of subclones with monosomy 7 and 
      deletion of the 20q13.2 region, which were not found in conventional cytogenetic 
      analysis in the exposed group (more than one Gy) compared to the non-exposed 
      controls. Furthermore, segmental jumping translocation (SJT) of the c-MYC gene 
      region was observed only in the exposed group. These chromosomal instability 
      suggested that the leukemic cells from the heavily exposed patients contained 
      persistent cellular genetic instability which may strongly influence the 
      development of leukemia in people exposed to radiation.
FAU - Nakanishi, M
AU  - Nakanishi M
AD  - Department of Cancer Cytogenetics, Hiroshima University, Japan. 
      mitsue@mcai.med.hiroshima-u.ac.jp
FAU - Tanaka, K
AU  - Tanaka K
FAU - Shintani, T
AU  - Shintani T
FAU - Takahashi, T
AU  - Takahashi T
FAU - Kamada, N
AU  - Kamada N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Radiat Res
JT  - Journal of radiation research
JID - 0376611
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - Leukemia, Myeloid, Acute/etiology/*genetics
MH  - Leukemia, Radiation-Induced/etiology/*genetics
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/etiology/*genetics
MH  - Nuclear Warfare
MH  - Radiation Injuries/etiology/*genetics
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
AID - 10.1269/jrr.40.159 [doi]
PST - ppublish
SO  - J Radiat Res. 1999 Jun;40(2):159-67. doi: 10.1269/jrr.40.159.