PMID- 10494182
OWN - NLM
STAT- MEDLINE
DCOM- 19991116
LR  - 20071115
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 56 Suppl 1
DP  - 1999
TI  - [The role of autologous hematopoietic cell transplantation in adult acute 
      myelogenous leukemia].
PG  - 44-51
AB  - High dose chemotherapy with autologous hemopoietic cell transplantation (AHCT) is 
      a common method of treatment of acute myelogenous leukemia (AML). AHCT is a 
      treatment of choice for patients who have no matched family donor. AHCT is 
      particularly recommended for older patients, excluded from allogeneic 
      transplantation procedures. Prospective randomised trials have shown better 
      efficacy of AHCT comparing with conventional chemotherapy in postremission 
      treatment of AML. Both in vitro and in vivo bone marrow purging allow to achieve 
      better transplantation results. Since two years peripheral blood instead of bone 
      marrow is increasingly used as a source of transplant material. It allows more 
      rapid hemopoiesis regrowth. Various methods of immunotherapy such as 
      interleukin-2, Linomid and mixed hemopoietic cell transplantation (delayed donor 
      lymphocytes transfusion) are used to evoke an autologous graft versus leukemia 
      (GvL) phenomenon and to reduce AML relapse rate. Analysis of prognostic factors 
      allows to identify a group of AML patients for whom AHCT is strongly recommended.
FAU - Rucinska, M
AU  - Rucinska M
AD  - Kliniki Hematologii Collegium Medicum, Uniwersytetu Jagiellonksiego w Krakowie.
FAU - Machaczka, M
AU  - Machaczka M
FAU - Piatkowska-Jakubas, B
AU  - Piatkowska-Jakubas B
FAU - Skotnicki, A B
AU  - Skotnicki AB
LA  - pol
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Rola autologicznego przeszczepiania komorek hemopoetycznych w leczeniu ostrej 
      bialaczki szpikowej u doroslych.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Bone Marrow Purging
MH  - Bone Marrow Transplantation/methods
MH  - Combined Modality Therapy
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Humans
MH  - Immunotherapy
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Prognosis
MH  - Randomized Controlled Trials as Topic
RF  - 36
EDAT- 1999/09/24 00:00
MHDA- 1999/09/24 00:01
CRDT- 1999/09/24 00:00
PHST- 1999/09/24 00:00 [pubmed]
PHST- 1999/09/24 00:01 [medline]
PHST- 1999/09/24 00:00 [entrez]
PST - ppublish
SO  - Przegl Lek. 1999;56 Suppl 1:44-51.