PMID- 10499792
OWN - NLM
STAT- MEDLINE
DCOM- 19991015
LR  - 20220309
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 98
IP  - 6
DP  - 1999 Sep 17
TI  - BDNF regulates the maturation of inhibition and the critical period of plasticity 
      in mouse visual cortex.
PG  - 739-55
AB  - Maturation of the visual cortex is influenced by visual experience during an 
      early postnatal period. The factors that regulate such a critical period remain 
      unclear. We examined the maturation and plasticity of the visual cortex in 
      transgenic mice in which the postnatal rise of brain-derived neurotrophic factor 
      (BDNF) was accelerated. In these mice, the maturation of GABAergic innervation 
      and inhibition was accelerated. Furthermore, the age-dependent decline of 
      cortical long-term potentiation induced by white matter stimulation, a form of 
      synaptic plasticity sensitive to cortical inhibition, occurred earlier. Finally, 
      transgenic mice showed a precocious development of visual acuity and an earlier 
      termination of the critical period for ocular dominance plasticity. We propose 
      that BDNF promotes the maturation of cortical inhibition during early postnatal 
      life, thereby regulating the critical period for visual cortical plasticity.
FAU - Huang, Z J
AU  - Huang ZJ
AD  - Center for Learning and Memory, Department of Biology, Massachusetts Institute of 
      Technology, Cambridge 02139, USA.
FAU - Kirkwood, A
AU  - Kirkwood A
FAU - Pizzorusso, T
AU  - Pizzorusso T
FAU - Porciatti, V
AU  - Porciatti V
FAU - Morales, B
AU  - Morales B
FAU - Bear, M F
AU  - Bear MF
FAU - Maffei, L
AU  - Maffei L
FAU - Tonegawa, S
AU  - Tonegawa S
LA  - eng
GR  - NS32925/NS/NINDS NIH HHS/United States
GR  - R01EY12124-01/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Parvalbumins)
RN  - 0 (Receptors, GABA)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Cerebral Cortex/physiology
MH  - Evoked Potentials
MH  - Interneurons
MH  - Long-Term Potentiation
MH  - Mice
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Neural Inhibition/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Parvalbumins/isolation & purification
MH  - Perception/physiology
MH  - Prosencephalon/physiology
MH  - Pyramidal Cells
MH  - *Receptors, GABA
MH  - Recombinant Proteins/metabolism
MH  - Time Factors
MH  - Tissue Distribution
MH  - Transgenes
MH  - Visual Acuity
MH  - Visual Cortex/*physiology
EDAT- 1999/09/28 00:00
MHDA- 1999/09/28 00:01
CRDT- 1999/09/28 00:00
PHST- 1999/09/28 00:00 [pubmed]
PHST- 1999/09/28 00:01 [medline]
PHST- 1999/09/28 00:00 [entrez]
AID - S0092-8674(00)81509-3 [pii]
AID - 10.1016/s0092-8674(00)81509-3 [doi]
PST - ppublish
SO  - Cell. 1999 Sep 17;98(6):739-55. doi: 10.1016/s0092-8674(00)81509-3.