PMID- 105012
OWN - NLM
STAT- MEDLINE
DCOM- 19790425
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 63
IP  - 1
DP  - 1979 Jan
TI  - A study of human leukocyte D locus related antigens in Graves' disease.
PG  - 108-13
AB  - An association between Graves' disease and the human leukocyte antigen (HLA) 
      system has previously been reported. The disease was more strongly associated 
      with the HLA D locus antigen Dw3 than with HLA B8. Products of the HLA D locus 
      are determined by the interaction of test cells with standard typing lymphocytes, 
      a technically difficult procedure. Recently, it has been possible to type 
      serologically for D locus related (DRw) specificities on peripheral bone 
      marrow-derived (B) lymphocytes. Blood B lymphocytes from 50 unrelated controls 
      and 41 patients with Graves' disease were typed for seven HLA DRw specificities. 
      28 patients with Graves' disease (68%) were positive for DRw3, in contrast to 14 
      controls (28%); whereas only 21 patients (50%) were HLA B8 positive, compared 
      with 13 (26%) controls. Thus, positivity for DRw3 afforded a relative risk for 
      Graves' disease of 5.5, whereas that for HLA B8 amounted to 3.0. Additionally, a 
      family with multiple cases of Graves' disease in which the disease was previously 
      shown to be inherited with the haplotype, was linked to DRw2, which suggests that 
      the susceptibility to the disease was inherited in association with that antigen. 
      Two HLA B/glyoxalase recombination events were observed in this family; in both 
      instances HLA DRw followed HLA B. This study thus demonstrates that the disease 
      susceptibility gene for Graves' disease is in strong linkage disequilibrium with 
      DRw3; however, it may be associated with other DRw specificities and inherited 
      within family units in association with them.
FAU - Farid, N R
AU  - Farid NR
FAU - Sampson, L
AU  - Sampson L
FAU - Noel, E P
AU  - Noel EP
FAU - Barnard, J M
AU  - Barnard JM
FAU - Mandeville, R
AU  - Mandeville R
FAU - Larsen, B
AU  - Larsen B
FAU - Marshall, W H
AU  - Marshall WH
FAU - Carter, N D
AU  - Carter ND
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Female
MH  - Genes, MHC Class II
MH  - Graves Disease/genetics/*immunology
MH  - *HLA Antigens/genetics
MH  - Humans
MH  - Male
MH  - Pedigree
MH  - Pregnancy
PMC - PMC371924
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
PMCR- 1979/01/01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
PHST- 1979/01/01 00:00 [pmc-release]
AID - 10.1172/JCI109263 [doi]
PST - ppublish
SO  - J Clin Invest. 1979 Jan;63(1):108-13. doi: 10.1172/JCI109263.