PMID- 10502318
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20191024
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 26
IP  - 3
DP  - 1999 Nov
TI  - A biological role for deletions in chromosomal band 13q14 in mantle cell and 
      peripheral t-cell lymphomas?
PG  - 210-4
AB  - Structural aberrations of chromosomal band 13q14 are frequent in B-cell chronic 
      lymphocytic leukemia (B-CLL) and target a putative tumor suppressor gene in the 
      genomic region between the RB1 gene and the genetic marker D13S25. Recently, it 
      has been suggested that alterations of this particular region might also be of 
      relevance for the pathogenesis of mantle cell lymphomas (MCL). We applied 
      dual-color fluorescence in situ hybridization (FISH) using probes for the RB1 
      and/or D13S25 loci and screened a total of 236 B- and T-cell non-Hodgkin's 
      lymphomas (NHL) for deletions occurring in this genomic region. In MCL, the high 
      rate (12/32; 38%) of hemizygous deletions and especially a deletion pattern 
      similar to B-CLL in four of the cases provide further evidence that a substantial 
      proportion of MCL cases may share a common way of pathogenesis with B-CLL. In 
      other B-cell NHL, the frequency of allelic loss affecting 13q14 was overall low. 
      However, the finding of 13q14 microdeletions in seven cases without detectable 
      alterations of chromosome 13 at G-banding analysis might indicate a possible 
      involvement of this genetic region also for the lymphomagenesis of single cases 
      of B-cell NHL other than B-CLL and MCL. In T-cell NHL, allelic loss at 13q14 was 
      encountered in three of 13 peripheral T-NHL, NOS. Taking into account the very 
      limited cytogenetic data yet available in this entity, our series provides 
      further evidence that 13q14 changes might represent one of the most frequent 
      genetic abnormalities in T-cell NHL.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Rosenwald, A
AU  - Rosenwald A
AD  - Institute of Pathology, University of Wurzburg, Germany.
FAU - Ott, G
AU  - Ott G
FAU - Krumdiek, A K
AU  - Krumdiek AK
FAU - Dreyling, M H
AU  - Dreyling MH
FAU - Katzenberger, T
AU  - Katzenberger T
FAU - Kalla, J
AU  - Kalla J
FAU - Roth, S
AU  - Roth S
FAU - Ott, M M
AU  - Ott MM
FAU - Muller-Hermelink, H K
AU  - Muller-Hermelink HK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
SB  - IM
MH  - Chromosome Banding
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 13
MH  - Genes, Retinoblastoma/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Mantle-Cell/*genetics
MH  - Lymphoma, T-Cell, Peripheral/*genetics
EDAT- 1999/09/29 00:00
MHDA- 1999/09/29 00:01
CRDT- 1999/09/29 00:00
PHST- 1999/09/29 00:00 [pubmed]
PHST- 1999/09/29 00:01 [medline]
PHST- 1999/09/29 00:00 [entrez]
AID - 10.1002/(SICI)1098-2264(199911)26:3<210::AID-GCC4>3.0.CO;2-J [pii]
AID - 10.1002/(sici)1098-2264(199911)26:3<210::aid-gcc4>3.0.co;2-j [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1999 Nov;26(3):210-4. doi: 
      10.1002/(sici)1098-2264(199911)26:3<210::aid-gcc4>3.0.co;2-j.