PMID- 10503881
OWN - NLM
STAT- MEDLINE
DCOM- 19991007
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 144
IP  - 1
DP  - 1999 Sep 20
TI  - Analysis of the MEN1 gene in sporadic pituitary adenomas from Japanese patients.
PG  - 85-92
AB  - An autosomal-dominant syndrome known as multiple endocrine neoplasia type 1 
      (MEN1) is characterized by tumors in parathyroid glands, pancreatic endocrine 
      tissues and the anterior pituitary gland. The predisposing gene was identified at 
      11q13 when germline mutations in the MEN1 gene were detected in affected 
      pedigrees. To investigate a possible role of this gene in tumorigenesis of 
      non-familial pituitary adenomas, we examined 24 sporadic tumors from Japanese 
      patients for loss of heterozygosity (LOH) at the 11q13 region and for somatic 
      mutations in the entire coding region and exon-intron boundaries of MEN1. 
      Although three common sequence variants were detected, none of the tumors 
      exhibited either LOH or somatic mutations of this gene. Our results indicate that 
      inherited and sporadic forms of pituitary adenomas are different in terms of the 
      genetic events that contribute to their development, and that other loci 
      associated with pituitary neoplasia must still be sought.
FAU - Fukino, K
AU  - Fukino K
AD  - Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 
      Kawasaki-shi, Japan.
FAU - Kitamura, Y
AU  - Kitamura Y
FAU - Sanno, N
AU  - Sanno N
FAU - Teramoto, A
AU  - Teramoto A
FAU - Emi, M
AU  - Emi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenoma/*genetics
MH  - Exons
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - Pituitary Neoplasms/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single-Stranded Conformational
MH  - *Proto-Oncogene Proteins
EDAT- 1999/09/30 00:00
MHDA- 1999/09/30 00:01
CRDT- 1999/09/30 00:00
PHST- 1999/09/30 00:00 [pubmed]
PHST- 1999/09/30 00:01 [medline]
PHST- 1999/09/30 00:00 [entrez]
AID - S0304383599002013 [pii]
AID - 10.1016/s0304-3835(99)00201-3 [doi]
PST - ppublish
SO  - Cancer Lett. 1999 Sep 20;144(1):85-92. doi: 10.1016/s0304-3835(99)00201-3.