PMID- 10503900
OWN - NLM
STAT- MEDLINE
DCOM- 19991012
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 143
IP  - 2
DP  - 1999 Sep 1
TI  - Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis.
PG  - 179-83
AB  - The cooking of meat and fish produces heterocyclic amine mutagens, including 
      2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 
      2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Chronic administration of PhIP or 
      IQ to the F344 rat induces tumors at several sites, including adenocarcinomas of 
      the colon, and short-term treatment leads to the formation of colonic aberrant 
      crypt foci (ACF). We have used these end-points to identify potential 
      chemopreventive agents that might be effective against heterocyclic amine colon 
      carcinogens. Typically, IQ or PhIP were administered to groups of 10-15 rats by 
      oral gavage on alternating days in weeks 3 and 4, and ACF were scored after 8, 
      12, or 16 weeks or tumors were detected at 52 weeks. To distinguish between 
      'blocking' and 'suppressing' agents, potential inhibitors were administered 
      during the initiation or post-initiation phases, respectively, and subsequent 
      studies focused on the inhibitory mechanisms. Among the most effective inhibitors 
      identified to date, and their major mechanisms, were the following: chlorophyllin 
      (molecular complex formation); indole-3-carbinol (inhibition and induction of 
      cytochromes P450 and phase II enzymes); green and black tea catechins (induction 
      of UDP-glucuronosyl transferase, inhibition of NADPH-cytochrome P450 reductase, 
      scavenging of reactive intermediates); and conjugated linoleic acids (inhibition 
      of cytochrome P450 and prostaglandin H synthase).
FAU - Xu, M
AU  - Xu M
AD  - The Linus Pauling Institute, and Department of Environmental and Molecular 
      Toxicology, Oregon State University, Corvallis 97331-6512, USA.
FAU - Dashwood, R H
AU  - Dashwood RH
LA  - eng
GR  - R01 CA065525-06A1/CA/NCI NIH HHS/United States
GR  - CA65525/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Carcinogens)
RN  - 0 (Chlorophyllides)
RN  - 0 (Imidazoles)
RN  - 0 (Indoles)
RN  - 0 (Quinolines)
RN  - 30GL3D3T0G (2-amino-3-methylimidazo(4,5-f)quinoline)
RN  - 8R1V1STN48 (Catechin)
RN  - 909C6UN66T (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - C11E72455F (indole-3-carbinol)
RN  - EEM82VOY7C (chlorophyllin)
SB  - IM
MH  - Animals
MH  - Anticarcinogenic Agents/*pharmacology/therapeutic use
MH  - Carcinogens/administration & dosage/*toxicity
MH  - Catechin/pharmacology/therapeutic use
MH  - Chlorophyllides/pharmacology/therapeutic use
MH  - Colon/drug effects/pathology
MH  - Colonic Neoplasms/*chemically induced/*prevention & control
MH  - Drug Antagonism
MH  - Imidazoles/administration & dosage/*toxicity
MH  - Indoles/*pharmacology/therapeutic use
MH  - Linoleic Acid/pharmacology/therapeutic use
MH  - Precancerous Conditions/chemically induced/prevention & control
MH  - Quinolines/administration & dosage/*toxicity
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 1999/09/30 00:00
MHDA- 1999/09/30 00:01
CRDT- 1999/09/30 00:00
PHST- 1999/09/30 00:00 [pubmed]
PHST- 1999/09/30 00:01 [medline]
PHST- 1999/09/30 00:00 [entrez]
AID - S0304383599001214 [pii]
AID - 10.1016/s0304-3835(99)00121-4 [doi]
PST - ppublish
SO  - Cancer Lett. 1999 Sep 1;143(2):179-83. doi: 10.1016/s0304-3835(99)00121-4.